 HIV Integrase Inhibitors
"HIV Integrase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Inhibitors of HIV INTEGRASE, an enzyme required for integration of viral DNA into cellular DNA.
| Descriptor ID |
D019428
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| MeSH Number(s) |
D27.505.519.389.375.400 D27.505.954.122.388.077.088.314
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "HIV Integrase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "HIV Integrase Inhibitors".
This graph shows the total number of publications written about "HIV Integrase Inhibitors" by people in this website by year, and whether "HIV Integrase Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2004 | 2 | 1 | 3 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "HIV Integrase Inhibitors" by people in Profiles.
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Nunthaboot N, Pianwanit S, Parasuk V, Ebalunode JO, Briggs JM, Kokpol S. Hybrid quantum mechanical/molecular mechanical molecular dynamics simulations of HIV-1 integrase/inhibitor complexes. Biophys J. 2007 Nov 15; 93(10):3613-26.
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Deng J, Sanchez T, Neamati N, Briggs JM. Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors. J Med Chem. 2006 Mar 09; 49(5):1684-92.
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Brigo A, Mustata GI, Briggs JM, Moro S. Discovery of HIV-1 integrase inhibitors through a novel combination of ligand and structure-based drug design. Med Chem. 2005 May; 1(3):263-75.
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Brigo A, Lee KW, Iurcu Mustata G, Briggs JM. Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain. Biophys J. 2005 May; 88(5):3072-82.
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Deng J, Lee KW, Sanchez T, Cui M, Neamati N, Briggs JM. Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors. J Med Chem. 2005 Mar 10; 48(5):1496-505.
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Barreca ML, Rao A, De Luca L, Zappalà M, Gurnari C, Monforte P, De Clercq E, Van Maele B, Debyser Z, Witvrouw M, Briggs JM, Chimirri A. Efficient 3D database screening for novel HIV-1 IN inhibitors. J Chem Inf Comput Sci. 2004 Jul-Aug; 44(4):1450-5.
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Mustata GI, Brigo A, Briggs JM. HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors. Bioorg Med Chem Lett. 2004 Mar 22; 14(6):1447-54.
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Adesokan AA, Roberts VA, Lee KW, Lins RD, Briggs JM. Prediction of HIV-1 integrase/viral DNA interactions in the catalytic domain by fast molecular docking. J Med Chem. 2004 Feb 12; 47(4):821-8.
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Carlson HA, Masukawa KM, Rubins K, Bushman FD, Jorgensen WL, Lins RD, Briggs JM, McCammon JA. Developing a dynamic pharmacophore model for HIV-1 integrase. J Med Chem. 2000 Jun 01; 43(11):2100-14.
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