 Peptoids
"Peptoids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
| Descriptor ID |
D034444
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| MeSH Number(s) |
D12.644.679
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peptoids".
Below are MeSH descriptors whose meaning is more specific than "Peptoids".
This graph shows the total number of publications written about "Peptoids" by people in this website by year, and whether "Peptoids" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 3 | 0 | 3 | | 2009 | 1 | 0 | 1 | | 2010 | 3 | 0 | 3 | | 2011 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peptoids" by people in Profiles.
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Desai TJ, Udugamasooriya DG. A comprehensive lipid binding and activity validation of a cancer-specific peptide-peptoid hybrid PPS1. Biochem Biophys Res Commun. 2017 Apr 29; 486(2):545-550.
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Singh J, Shukla SP, Desai TJ, Udugamasooriya DG. Identification of the minimum pharmacophore of lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1D1. Bioorg Med Chem. 2016 Sep 15; 24(18):4470-4477.
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Matharage JM, Minna JD, Brekken RA, Udugamasooriya DG. Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells. ACS Chem Biol. 2015 Dec 18; 10(12):2891-9.
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Hooks JC, Matharage JP, Udugamasooriya DG. Development of homomultimers and heteromultimers of lung cancer-specific peptoids. Biopolymers. 2011; 96(5):567-77.
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De León-Rodríguez LM, Lubag A, Udugamasooriya DG, Proneth B, Brekken RA, Sun X, Kodadek T, Dean Sherry A. MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. J Am Chem Soc. 2010 Sep 22; 132(37):12829-31.
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Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ, Brekken RA. GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer. BMC Cancer. 2010 Jul 30; 10:397.
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Lee J, Udugamasooriya DG, Lim HS, Kodadek T. Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates. Nat Chem Biol. 2010 Apr; 6(4):258-60.
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Gocke AR, Udugamasooriya DG, Archer CT, Lee J, Kodadek T. Isolation of antagonists of antigen-specific autoimmune T cell proliferation. Chem Biol. 2009 Nov 25; 16(11):1133-9.
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Udugamasooriya DG, Dunham G, Ritchie C, Brekken RA, Kodadek T. The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5892-4.
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Udugamasooriya DG, Ritchie C, Brekken RA, Kodadek T. A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site. Bioorg Med Chem. 2008 Jun 15; 16(12):6338-43.
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