 Ligands
"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
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| MeSH Number(s) |
D27.720.470.480
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 3 | 3 | | 1998 | 1 | 1 | 2 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 5 | 5 | | 2002 | 1 | 7 | 8 | | 2003 | 0 | 7 | 7 | | 2004 | 0 | 10 | 10 | | 2005 | 0 | 10 | 10 | | 2006 | 1 | 6 | 7 | | 2007 | 0 | 10 | 10 | | 2008 | 1 | 8 | 9 | | 2009 | 0 | 9 | 9 | | 2010 | 1 | 7 | 8 | | 2011 | 1 | 7 | 8 | | 2012 | 0 | 11 | 11 | | 2013 | 0 | 3 | 3 | | 2014 | 1 | 6 | 7 | | 2015 | 0 | 6 | 6 | | 2016 | 0 | 2 | 2 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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JavanMoghadam S, Weihua Z, Hunt KK, Keyomarsi K. Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion. Cell Cycle. 2016 Jun 17; 15(12):1579-90.
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Loftus LM, White JK, Albani BA, Kohler L, Kodanko JJ, Thummel RP, Dunbar KR, Turro C. New Ru(II) Complex for Dual Activity: Photoinduced Ligand Release and (1)O2 Production. Chemistry. 2016 Mar 07; 22(11):3704-8.
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Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24; 58(24):9578-90.
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Hoffmann C, Castro M, Rinken A, Leurs R, Hill SJ, Vischer HF. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It. Mol Pharmacol. 2015 Sep; 88(3):552-60.
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Stoddart LA, Johnstone EKM, Wheal AJ, Goulding J, Robers MB, Machleidt T, Wood KV, Hill SJ, Pfleger KDG. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015 Jul; 12(7):661-663.
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Stoddart LA, Kilpatrick LE, Briddon SJ, Hill SJ. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands. Neuropharmacology. 2015 Nov; 98:48-57.
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Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 2015 Nov; 98:68-77.
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Gherbi K, May LT, Baker JG, Briddon SJ, Hill SJ. Negative cooperativity across ß1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 ß1-adrenoceptor binding conformation. FASEB J. 2015 Jul; 29(7):2859-71.
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Cheng G, Zhong M, Kawaguchi R, Kassai M, Al-Ubaidi M, Deng J, Ter-Stepanian M, Sun H. Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. Elife. 2014 Dec 23; 3:e05401.
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Filgueira CS, Benod C, Lou X, Gunamalai PS, Villagomez RA, Strom A, Gustafsson JÅ, Berkenstam AL, Webb P. A screening cascade to identify ERß ligands. Nucl Recept Signal. 2014; 12:e003.
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