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Bradley McConnell

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutic
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-1218
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    Collapse Research 
    Collapse research activities and funding
    R01HL085487     (MCCONNELL, BRADLEY K)Sep 30, 2007 - Mar 31, 2014
    NIH/NHLBI
    Targeted Disruption of Beta-Adrenergic Signaling to Increase Cardiac Contractilit
    Role: Principal Investigator
    R15HL124458     (MCCONNELL, BRADLEY K)Apr 1, 2015 - Mar 31, 2018
    NIH/NHLBI
    Scaffolding Protein Interaction Network Regulates Cardiac Cell Signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li Z, Singh S, Suryavanshi SV, Ding W, Shen X, Wijaya CS, Gao WD, McConnell BK. Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol. 2017 Jul 15; 807:117-126. PMID: 28428008.
      View in: PubMed
    2. Liu Y, Chen L, Diaz AD, Benham A, Xu X, Wijaya CS, Fa'ak F, Luo W, Soibam B, Azares A, Yu W, Lyu Q, Stewart MD, Gunaratne P, Cooney A, McConnell BK, Schwartz RJ. Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts. Sci Rep. 2016 Aug 19; 6:31457. PMID: 27538477; PMCID: PMC4990963.
      View in: PubMed, PubMed Central
    3. Valenzuela N, Fan Q, Fa'ak F, Soibam B, Nagandla H, Liu Y, Schwartz RJ, McConnell BK, Stewart MD. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016 Mar; 9(3):335-45. PMID: 26935106; PMCID: PMC4833330.
      View in: PubMed, PubMed Central
    4. Rababa'h AM, Deo SV, Altarabsheh SE, De Caro J, Tarboush NA, Alzoubi KH, Ababneh M, McConnell BK, Markowitz AH, Park SJ. N-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery. Heart Surg Forum. 2016 Feb 22; 19(1):E16-22. PMID: 26913679.
      View in: PubMed
    5. McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB. Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Front Physiol. 2015; 6:242. PMID: 26379556; PMCID: PMC4550777.
      View in: PubMed, PubMed Central
    6. Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9046-51. PMID: 26153423; PMCID: PMC4517252.
      View in: PubMed, PubMed Central
    7. Rababa'h A, Singh S, Suryavanshi SV, Altarabsheh SE, Deo SV, McConnell BK. Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy. Int J Mol Sci. 2014 Dec 24; 16(1):218-29. PMID: 25547489; PMCID: PMC4307244.
      View in: PubMed, PubMed Central
    8. Motawea HK, Blazek AD, Zirwas MJ, Pleister AP, Ahmed AA, McConnell BK, Chotani MA. Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-a2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells. J Cytol Mol Biol. 2014 Jan 10; 1(1). PMID: 24701590.
      View in: PubMed
    9. Guillory AN, Yin X, Wijaya CS, Diaz Diaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK. Enhanced cardiac function in Gravin mutant mice involves alterations in the ß-adrenergic receptor signaling cascade. PLoS One. 2013; 8(9):e74784. PMID: 24058627; PMCID: PMC3776749.
      View in: PubMed, PubMed Central
    10. Rababa'h A, Craft JW, Wijaya CS, Atrooz F, Fan Q, Singh S, Guillory AN, Katsonis P, Lichtarge O, McConnell BK. Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88. PMID: 23806656; PMCID: PMC3808176.
      View in: PubMed, PubMed Central
    11. Nguyen VT, Wu Y, Guillory AN, McConnell BK, Fujise K, Huang MH. Delta-opioid augments cardiac contraction through ß-adrenergic and CGRP-receptor co-signaling. Peptides. 2012 Jan; 33(1):77-82. PMID: 22108711; PMCID: PMC3396132.
      View in: PubMed, PubMed Central
    12. Huang MH, Wu Y, Nguyen V, Rastogi S, McConnell BK, Wijaya C, Uretsky BF, Poh KK, Tan HC, Fujise K. Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. Cardiovasc Drugs Ther. 2011 Jun; 25(3):223-32. PMID: 21562974; PMCID: PMC3110274.
      View in: PubMed, PubMed Central
    13. Wu Y, Yin X, Wijaya C, Huang MH, McConnell BK. Acute myocardial infarction in rats. J Vis Exp. 2011 Feb 16; (48). PMID: 21372786; PMCID: PMC3197402.
      View in: PubMed, PubMed Central
    14. McConnell BK, Popovic Z, Mal N, Lee K, Bautista J, Forudi F, Schwartzman R, Jin JP, Penn M, Bond M. Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis. J Biol Chem. 2009 Jan 16; 284(3):1583-92. PMID: 18945669; PMCID: PMC2615525.
      View in: PubMed, PubMed Central
    15. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1):73-80. PMID: 27520666.
      View in: PubMed
    16. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1-2):73-80. PMID: 15524168.
      View in: PubMed
    17. Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW, Kranias EG. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest. 2003 Mar; 111(6):859-67. PMID: 12639992; PMCID: PMC153769.
      View in: PubMed, PubMed Central
    18. Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG. The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest. 2002 Apr; 109(8):1013-20. PMID: 11956238; PMCID: PMC150949.
      View in: PubMed, PubMed Central
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