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Alexander Statsyuk

TitleAssistant Professor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutic
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Research 
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    R01GM115632     (STATSYUK, ALEXANDER V)Jul 1, 2015 - Jun 30, 2020
    NIH/NIGMS
    Pharmacological Inhibitors of Nedd4 ubiquitin ligase as anticancer therapeutics
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Foote PK, Krist DT, Statsyuk AV. High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor. Curr Protoc Chem Biol. 2017 Sep 14; 9(3):174-195. PMID: 28910856.
      View in: PubMed
    2. Park S, Foote PK, Krist DT, Rice SE, Statsyuk AV. UbMES and UbFluor: Novel Probes For RBR E3 Ubiquitin Ligase PARKIN. J Biol Chem. 2017 Jul 14. PMID: 28710279.
      View in: PubMed
    3. Misra M, Kuhn M, Löbel M, An H, Statsyuk AV, Sotriffer C, Schindelin H. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 Jul 05; 25(7):1120-1129.e3. PMID: 28578874.
      View in: PubMed
    4. Krist DT, Foote PK, Statsyuk AV. UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis. Curr Protoc Chem Biol. 2017 Mar 02; 9(1):11-37. PMID: 28253433.
      View in: PubMed
    5. Krist DT, Park S, Boneh GH, Rice SE, Statsyuk AV. UbFluor: A Mechanism-Based Probe for HECT E3 Ligases. Chem Sci. 2016 Aug 01; 7(8):5587-5595. PMID: 27482366.
      View in: PubMed
    6. Kathman SG, Statsyuk AV. Covalent Tethering of Fragments For Covalent Probe Discovery. Medchemcomm. 2016 Apr 01; 7(4):576-585. PMID: 27398190.
      View in: PubMed
    7. An H, Statsyuk AV. Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis. Chem Commun (Camb). 2016 Feb 11; 52(12):2477-80. PMID: 26575161.
      View in: PubMed
    8. Kathman SG, Span I, Smith AT, Xu Z, Zhan J, Rosenzweig AC, Statsyuk AV. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 07; 137(39):12442-5. PMID: 26371805; PMCID: PMC4669213.
      View in: PubMed, PubMed Central
    9. McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorg Med Chem Lett. 2015 Oct 15; 25(20):4509-12. PMID: 26342866; PMCID: PMC4592840 [Available on 10/15/16].
      View in: PubMed, PubMed Central
    10. Krist DT, Statsyuk AV. Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers. Biochemistry. 2015 Jul 28; 54(29):4411-4. PMID: 26161728; PMCID: PMC4527872.
      View in: PubMed, PubMed Central
    11. An H, Statsyuk AV. An inhibitor of ubiquitin conjugation and aggresome formation. Chem Sci. 2015 Sep 01; 6(9):5235-5245. PMID: 28717502.
      View in: PubMed
    12. Park S, Krist DT, Statsyuk AV. Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes. Chem Sci. 2015 Mar 01; 6(3):1770-1779. PMID: 28706640.
      View in: PubMed
    13. Kathman SG, Xu Z, Statsyuk AV. A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem. 2014 Jun 12; 57(11):4969-74. PMID: 24870364; PMCID: PMC4113264.
      View in: PubMed, PubMed Central
    14. An H, Krist DT, Statsyuk AV. Crosstalk between kinases and Nedd4 family ubiquitin ligases. Mol Biosyst. 2014 Jul; 10(7):1643-57. PMID: 24457516.
      View in: PubMed
    15. An H, Statsyuk AV. Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways. J Am Chem Soc. 2013 Nov 13; 135(45):16948-62. PMID: 24138456.
      View in: PubMed
    16. Hong CM, Statsyuk AV. The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles. Org Biomol Chem. 2013 May 14; 11(18):2932-5. PMID: 23536160.
      View in: PubMed
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