Adrenergic alpha-Antagonists
"Adrenergic alpha-Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Descriptor ID |
D000317
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MeSH Number(s) |
D27.505.519.625.050.200.100 D27.505.696.577.050.200.100
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Concept/Terms |
Adrenergic alpha-Antagonists- Adrenergic alpha-Antagonists
- Adrenergic alpha Antagonists
- alpha-Antagonists, Adrenergic
- Adrenergic alpha-Receptor Blockaders
- Adrenergic alpha Receptor Blockaders
- Blockaders, Adrenergic alpha-Receptor
- alpha-Receptor Blockaders, Adrenergic
- alpha-Adrenergic Blocking Agents
- Agents, alpha-Adrenergic Blocking
- Blocking Agents, alpha-Adrenergic
- alpha Adrenergic Blocking Agents
- alpha-Adrenergic Blockers
- Blockers, alpha-Adrenergic
- alpha Adrenergic Blockers
- alpha-Blockers, Adrenergic
- alpha Blockers, Adrenergic
- alpha-Adrenergic Receptor Blockaders
- Blockaders, alpha-Adrenergic Receptor
- Receptor Blockaders, alpha-Adrenergic
- alpha Adrenergic Receptor Blockaders
- Adrenergic alpha-Blockers
- Adrenergic alpha Blockers
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Below are MeSH descriptors whose meaning is more general than "Adrenergic alpha-Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Adrenergic alpha-Antagonists".
This graph shows the total number of publications written about "Adrenergic alpha-Antagonists" by people in this website by year, and whether "Adrenergic alpha-Antagonists" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1981 | 0 | 1 | 1 | 1982 | 1 | 0 | 1 | 1986 | 0 | 1 | 1 | 1987 | 1 | 0 | 1 | 1988 | 1 | 0 | 1 | 1991 | 0 | 1 | 1 | 1992 | 0 | 2 | 2 | 1993 | 1 | 1 | 2 | 1995 | 0 | 1 | 1 | 2001 | 0 | 1 | 1 | 2005 | 1 | 0 | 1 | 2006 | 0 | 1 | 1 | 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Adrenergic alpha-Antagonists" by people in Profiles.
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Salim S, Standifer KM, Eikenburg DC. Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells. J Pharmacol Exp Ther. 2007 Apr; 321(1):51-9.
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Zhang XY, Kosten TA. Previous exposure to cocaine enhances cocaine self-administration in an alpha 1-adrenergic receptor dependent manner. Neuropsychopharmacology. 2007 Mar; 32(3):638-45.
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Zhang XY, Kosten TA. Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. Biol Psychiatry. 2005 May 15; 57(10):1202-4.
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Bond RA. Is paradoxical pharmacology a strategy worth pursuing? Trends Pharmacol Sci. 2001 Jun; 22(6):273-6.
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Hieble JP, Bylund DB, Clarke DE, Eikenburg DC, Langer SZ, Lefkowitz RJ, Minneman KP, Ruffolo RR. International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev. 1995 Jun; 47(2):267-70.
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Gopalakrishnan SM, Chen C, Lokhandwala MF. Identification of alpha 1-adrenoceptor subtypes in rat renal proximal tubules. Eur J Pharmacol. 1993 Dec 21; 250(3):469-72.
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Hawk CT, Kudo LH, Rouch AJ, Schafer JA. Inhibition by epinephrine of AVP- and cAMP-stimulated Na+ and water transport in Dahl rat CCD. Am J Physiol. 1993 Sep; 265(3 Pt 2):F449-60.
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Alexander SP, Kendall DA, Hill SJ. Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate. J Neurochem. 1992 Aug; 59(2):610-5.
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Vyas SJ, Eichberg J, Lokhandwala MF. Characterization of receptors involved in dopamine-induced activation of phospholipase-C in rat renal cortex. J Pharmacol Exp Ther. 1992 Jan; 260(1):134-9.
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Eikenburg DC. Age-related changes in vascular sympathetic neurotransmission in the rat kidney. J Pharmacol Exp Ther. 1991 Oct; 259(1):176-81.
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People  People who have written about this concept. _
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