 Calmodulin
"Calmodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
| Descriptor ID |
D002147
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| MeSH Number(s) |
D12.644.360.381.249 D12.776.157.125.412.249 D12.776.476.387.249
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| Concept/Terms |
Calmodulin- Calmodulin
- Calcium-Dependent Regulator
- Calcium Dependent Regulator
- Calcium-Dependent Activator Protein
- Activator Protein, Calcium-Dependent
- Calcium Dependent Activator Protein
- Protein, Calcium-Dependent Activator
- Phosphodiesterase Protein Activator
- Activator, Phosphodiesterase Protein
- Protein Activator, Phosphodiesterase
- Phosphodiesterase Activating Factor
- Activating Factor, Phosphodiesterase
- Factor, Phosphodiesterase Activating
- Phosphodiesterase Activator Protein
- Activator Protein, Phosphodiesterase
- Protein, Phosphodiesterase Activator
- Regulator, Calcium-Dependent
- Regulator, Calcium Dependent
Cyclic AMP-Phosphodiesterase Activator- Cyclic AMP-Phosphodiesterase Activator
- AMP-Phosphodiesterase Activator, Cyclic
- Activator, Cyclic AMP-Phosphodiesterase
- Cyclic AMP Phosphodiesterase Activator
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Below are MeSH descriptors whose meaning is more general than "Calmodulin".
Below are MeSH descriptors whose meaning is more specific than "Calmodulin".
This graph shows the total number of publications written about "Calmodulin" by people in this website by year, and whether "Calmodulin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 3 | 3 | | 2008 | 0 | 3 | 3 | | 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calmodulin" by people in Profiles.
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Wang Q, Liang KC, Czader A, Waxham MN, Cheung MS. The effect of macromolecular crowding, ionic strength and calcium binding on calmodulin dynamics. PLoS Comput Biol. 2011 Jul; 7(7):e1002114.
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Alzoubi KH, Alkadhi KA. Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats. Neurosci Res. 2009 Feb; 63(2):95-9.
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Jimenez ME, Bush K, Pawlik J, Sower L, Peterson JW, Gilbertson SR. Synthesis and screening of small molecule inhibitors of anthrax edema factor. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4215-8.
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Alzoubi KH, Aleisa AM, Alkadhi KA. Expression of gLTP in sympathetic ganglia from stress-hypertensive rats: molecular evidence. J Mol Neurosci. 2008 Jun; 35(2):201-9.
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Aleisa AM, Alzoubi KH, Gerges NZ, Alkadhi KA. Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF. Neurobiol Dis. 2006 Jun; 22(3):453-62.
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Aleisa AM, Alzoubi KH, Alkadhi KA. Nicotine prevents stress-induced enhancement of long-term depression in hippocampal area CA1: electrophysiological and molecular studies. J Neurosci Res. 2006 Feb 01; 83(2):309-17.
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Alzoubi KH, Aleisa AM, Alkadhi KA. Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation. Hippocampus. 2006; 16(10):861-74.
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Alzoubi KH, Gerges NZ, Alkadhi KA. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies. Exp Neurol. 2005 Oct; 195(2):330-41.
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Alzoubi KH, Aleisa AM, Alkadhi KA. Impairment of long-term potentiation in the CA1, but not dentate gyrus, of the hippocampus in Obese Zucker rats: role of calcineurin and phosphorylated CaMKII. J Mol Neurosci. 2005; 27(3):337-46.
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Gerges NZ, Aleisa AM, Schwarz LA, Alkadhi KA. Reduced basal CaMKII levels in hippocampal CA1 region: possible cause of stress-induced impairment of LTP in chronically stressed rats. Hippocampus. 2004; 14(3):402-10.
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