Cross-Linking Reagents
"Cross-Linking Reagents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Descriptor ID |
D003432
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MeSH Number(s) |
D27.720.470.410.210
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Concept/Terms |
Cross-Linking Reagents- Cross-Linking Reagents
- Reagents, Cross-Linking
- Crosslinking Reagents
- Reagents, Crosslinking
- Bifunctional Reagents
- Reagents, Bifunctional
- Cross Linking Reagents
- Linking Reagents, Cross
- Reagents, Cross Linking
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Below are MeSH descriptors whose meaning is more general than "Cross-Linking Reagents".
Below are MeSH descriptors whose meaning is more specific than "Cross-Linking Reagents".
This graph shows the total number of publications written about "Cross-Linking Reagents" by people in this website by year, and whether "Cross-Linking Reagents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1981 | 0 | 1 | 1 | 1989 | 1 | 0 | 1 | 2002 | 0 | 1 | 1 | 2007 | 1 | 1 | 2 | 2009 | 0 | 2 | 2 | 2010 | 1 | 0 | 1 | 2011 | 2 | 0 | 2 | 2013 | 2 | 0 | 2 | 2014 | 0 | 1 | 1 | 2015 | 1 | 0 | 1 | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cross-Linking Reagents" by people in Profiles.
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Singh M, Li J, Han Z, Vantipalli S, Liu CH, Wu C, Raghunathan R, Aglyamov SR, Twa MD, Larin KV. Evaluating the Effects of Riboflavin/UV-A and Rose-Bengal/Green Light Cross-Linking of the Rabbit Cornea by Noncontact Optical Coherence Elastography. Invest Ophthalmol Vis Sci. 2016 Jul 01; 57(9):OCT112-20.
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Krist DT, Statsyuk AV. Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers. Biochemistry. 2015 Jul 28; 54(29):4411-4.
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Li J, Han Z, Singh M, Twa MD, Larin KV. Differentiating untreated and cross-linked porcine corneas of the same measured stiffness with optical coherence elastography. J Biomed Opt. 2014 Nov; 19(11):110502.
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Spencer MK, Radzinski NP, Tripathi S, Chowdhury S, Herrin RP, Chandran NN, Daniel AK, West JD. Pronounced toxicity differences between homobifunctional protein cross-linkers and analogous monofunctional electrophiles. Chem Res Toxicol. 2013 Nov 18; 26(11):1720-9.
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Naticchia MR, Brown HA, Garcia FJ, Lamade AM, Justice SL, Herrin RP, Morano KA, West JD. Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells. Chem Res Toxicol. 2013 Mar 18; 26(3):490-7.
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Williams MP, Ethirajan M, Ohkubo K, Chen P, Pera P, Morgan J, White WH, Shibata M, Fukuzumi S, Kadish KM, Pandey RK. Synthesis, photophysical, electrochemical, tumor-imaging, and phototherapeutic properties of purpurinimide-N-substituted cyanine dyes joined with variable lengths of linkers. Bioconjug Chem. 2011 Nov 16; 22(11):2283-95.
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West JD, Stamm CE, Brown HA, Justice SL, Morano KA. Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chem Res Toxicol. 2011 Sep 19; 24(9):1457-9.
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West JD, Stamm CE, Kingsley PJ. Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent. Chem Res Toxicol. 2011 Jan 14; 24(1):81-8.
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Zhao R, Hammitt R, Thummel RP, Liu Y, Turro C, Snapka RM. Nuclear targets of photodynamic tridentate ruthenium complexes. Dalton Trans. 2009 Dec 28; (48):10926-31.
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Tang Y, Ballarini R, Buehler MJ, Eppell SJ. Deformation micromechanisms of collagen fibrils under uniaxial tension. J R Soc Interface. 2010 May 06; 7(46):839-50.
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