 Necrosis
"Necrosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
| Descriptor ID |
D009336
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| MeSH Number(s) |
C23.550.717 G04.299.139.638
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Necrosis".
Below are MeSH descriptors whose meaning is more specific than "Necrosis".
This graph shows the total number of publications written about "Necrosis" by people in this website by year, and whether "Necrosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 3 | 3 | | 2005 | 0 | 1 | 1 | | 2007 | 0 | 4 | 4 | | 2008 | 0 | 3 | 3 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 3 | 3 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Necrosis" by people in Profiles.
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Renshaw AA, Cheville JC. Quantitative tumour necrosis is an independent predictor of overall survival in clear cell renal cell carcinoma. Pathology. 2015 Jan; 47(1):34-7.
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McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One. 2013; 8(3):e56576.
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Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5685-8.
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Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15; 427(2):164-74.
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Tam MH, Wong GK, Ip M, Kam MK, Abrigo JM, Zhu XL, Poon WS. Management outcome of NPC-related and non-NPC-related brain abscess in Hong Kong. Clin Neurol Neurosurg. 2012 Jul; 114(6):560-3.
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Lafontant PJ, Burns AR, Grivas JA, Lesch MA, Lala TD, Reuter SP, Field LJ, Frounfelter TD. The giant danio (D. aequipinnatus) as a model of cardiac remodeling and regeneration. Anat Rec (Hoboken). 2012 Feb; 295(2):234-48.
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Ritchey ER, Code K, Zelinka CP, Scott MA, Fischer AJ. The chicken cornea as a model of wound healing and neuronal re-innervation. Mol Vis. 2011; 17:2440-54.
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Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010 May 15; 88(7):1569-76.
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You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1564-73.
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Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F. Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell. 2008 May; 13(5):420-31.
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