 Serotonin
"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
| Descriptor ID |
D012701
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| MeSH Number(s) |
D02.092.211.215.801.852 D03.438.473.914.814 D23.469.050.650
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| Concept/Terms |
Serotonin- Serotonin
- Hippophaine
- 5-Hydroxytryptamine
- 5 Hydroxytryptamine
- Enteramine
- 3-(2-Aminoethyl)-1H-indol-5-ol
- 5-HT
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Below are MeSH descriptors whose meaning is more general than "Serotonin".
Below are MeSH descriptors whose meaning is more specific than "Serotonin".
This graph shows the total number of publications written about "Serotonin" by people in this website by year, and whether "Serotonin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 1 | 2 | | 1981 | 2 | 0 | 2 | | 1983 | 1 | 0 | 1 | | 1986 | 0 | 1 | 1 | | 1987 | 1 | 0 | 1 | | 1988 | 2 | 0 | 2 | | 1989 | 2 | 0 | 2 | | 1990 | 0 | 1 | 1 | | 1992 | 1 | 0 | 1 | | 1994 | 0 | 1 | 1 | | 1995 | 3 | 0 | 3 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 2 | 2 | | 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Serotonin" by people in Profiles.
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Anastasio NC, Gilbertson SR, Bubar MJ, Agarkov A, Stutz SJ, Jeng Y, Bremer NM, Smith TD, Fox RG, Swinford SE, Seitz PK, Charendoff MN, Craft JW, Laezza FM, Watson CS, Briggs JM, Cunningham KA. Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior. J Neurosci. 2013 Jan 23; 33(4):1615-30.
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Alkadhi KA, Alzoubi KH, Aleisa AM, Tanner FL, Nimer AS. Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in rat sympathetic ganglia. Neurobiol Dis. 2005 Dec; 20(3):849-57.
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Sreemantula S, Boini KM, Koppula S, Kilari EK, Nammi S. Indirect biochemical evidence that reserpine methiodide produces selective depletion of peripheral biogenic amines in rats. Pharmazie. 2005 Apr; 60(4):294-7.
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Kosten TA, Zhang XY, Kehoe P. Infant rats with chronic neonatal isolation experience show decreased extracellular serotonin levels in ventral striatum at baseline and in response to cocaine. Brain Res Dev Brain Res. 2004 Aug 18; 152(1):19-24.
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Salgado-Commissariat D, Alkadhi KA. Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Neuropharmacology. 1997 Nov-Dec; 36(11-12):1705-12.
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Salgado-Commissariat D, Alkadhi KA. Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats. Brain Res. 1996 Dec 16; 743(1-2):212-6.
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Alkadhi KA, Salgado-Commissariat D, Hogan YH, Akpaudo SB. Induction and maintenance of ganglionic long-term potentiation require activation of 5-hydroxytryptamine (5-HT3) receptors. J Physiol. 1996 Oct 15; 496 ( Pt 2):479-89.
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Nagao T, Nakashima M, Smart FW, Bond RA, Morrison KJ, Vanhoutte PM. Potentiation of endothelium-dependent hyperpolarization to serotonin by dietary intake of NC 020, a defined fish oil, in the porcine coronary artery. J Cardiovasc Pharmacol. 1995 Nov; 26(5):679-81.
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Cooper JA, Hill SJ, Alexander SP, Rubin PC, Horn EH. Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets. Br J Clin Pharmacol. 1995 Jul; 40(1):43-50.
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Salgado D, Alkadhi KA. Inhibition of epileptiform activity by serotonin in rat CA1 neurons. Brain Res. 1995 Jan 16; 669(2):176-82.
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