 Tissue Distribution
"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
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| MeSH Number(s) |
G03.787.917 G07.690.725.949
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| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
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Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1985 | 0 | 1 | 1 | | 1986 | 0 | 1 | 1 | | 1987 | 0 | 1 | 1 | | 1988 | 0 | 2 | 2 | | 1992 | 0 | 3 | 3 | | 1994 | 0 | 4 | 4 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 4 | 4 | | 2000 | 0 | 4 | 4 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 6 | 6 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 6 | 6 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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Manchandani P, Zhou J, Ledesma KR, Truong LD, Chow DS, Eriksen JL, Tam VH. Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model. Antimicrob Agents Chemother. 2016 Feb; 60(2):1029-34.
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Kong Q, Chang LC, Takahashi K, Liu Q, Schulte DA, Lai L, Ibabao B, Lin Y, Stouffer N, Das Mukhopadhyay C, Xing X, Seyb KI, Cuny GD, Glicksman MA, Lin CL. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J Clin Invest. 2014 Mar; 124(3):1255-67.
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Su R, Ermilov SA, Liopo AV, Oraevsky AA. Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models. J Biomed Opt. 2012 Oct; 17(10):101506.
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Williams MP, Ethirajan M, Ohkubo K, Chen P, Pera P, Morgan J, White WH, Shibata M, Fukuzumi S, Kadish KM, Pandey RK. Synthesis, photophysical, electrochemical, tumor-imaging, and phototherapeutic properties of purpurinimide-N-substituted cyanine dyes joined with variable lengths of linkers. Bioconjug Chem. 2011 Nov 16; 22(11):2283-95.
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Gesteira TF, Coulson-Thomas VJ, Ogata FT, Farias EH, Cavalheiro RP, de Lima MA, Cunha GL, Nakayasu ES, Almeida IC, Toma L, Nader HB. A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model. Biochim Biophys Acta. 2011 Dec; 1814(12):1862-9.
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Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, Fountain MD, Dziadek O, Han D, Ma L, Kim J, Hawkins SM, Anderson ML, Matzuk MM, Gunaratne PH. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. PLoS One. 2010 Mar 10; 5(3):e9637.
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Lu W, Huang Q, Ku G, Wen X, Zhou M, Guzatov D, Brecht P, Su R, Oraevsky A, Wang LV, Li C. Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials. 2010 Mar; 31(9):2617-26.
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Kim EY, Chiu YH, Dryer SE. Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1379-88.
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Ahn SM, Byun K, Kim D, Lee K, Yoo JS, Kim SU, Jho EH, Simpson RJ, Lee B. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS One. 2008; 3(12):e3917.
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Ghosn MG, Carbajal EF, Befrui NA, Tuchin VV, Larin KV. Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera. J Biomed Opt. 2008 Mar-Apr; 13(2):021110.
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