 Phorbol 12,13-Dibutyrate
"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
| Descriptor ID |
D015240
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| MeSH Number(s) |
D02.455.849.291.500.510.700
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| Concept/Terms |
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
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Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in this website by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 0 | 2 | 2 | | 1993 | 1 | 2 | 3 | | 1994 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
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Self TJ, Oakley SM, Hill SJ. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells. Br J Pharmacol. 2005 Oct; 146(4):612-24.
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Asghar M, Kansra V, Hussain T, Lokhandwala MF. Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J Am Soc Nephrol. 2001 Feb; 12(2):226-32.
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Asghar M, Hussain T, Lokhandwala MF. Activation of dopamine D(1)-like receptor causes phosphorylation of alpha(1)-subunit of Na(+),K(+)-ATPase in rat renal proximal tubules. Eur J Pharmacol. 2001 Jan 05; 411(1-2):61-66.
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McCreath G, Hall IP, Hill SJ. Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells. Br J Pharmacol. 1994 Nov; 113(3):823-30.
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Dickenson JM, Hill SJ. Homologous and heterologous desensitization of histamine H1- and ATP-receptors in the smooth muscle cell line, DDT1MF-2: the role of protein kinase C. Br J Pharmacol. 1993 Dec; 110(4):1449-56.
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Iredale PA, Hill SJ. Increases in intracellular calcium via activation of an endogenous P2-purinoceptor in cultured CHO-K1 cells. Br J Pharmacol. 1993 Dec; 110(4):1305-10.
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Iredale PA, Martin KF, Hill SJ, Kendall DA. The effects of beta-phorbol-12,13 dibutyrate on agonist-induced increases in [Ca2+]i in N1E-115 cells. Differential modulation of responses to angiotensin II and bradykinin. Biochem Pharmacol. 1993 Feb 09; 45(3):611-7.
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Iredale PA, Martin KF, Alexander SP, Hill SJ, Kendall DA. Inositol 1,4,5-trisphosphate generation and calcium mobilisation via activation of an atypical P2 receptor in the neuronal cell line, N1E-115. Br J Pharmacol. 1992 Dec; 107(4):1083-7.
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Alexander SP, Kendall DA, Hill SJ. Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate. J Neurochem. 1992 Aug; 59(2):610-5.
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Zhu YY, Schwartz RJ, Crow MT. Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization. J Cell Biol. 1991 Nov; 115(3):745-54.
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