 Receptor, Adenosine A3
"Receptor, Adenosine A3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.
| Descriptor ID |
D043684
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| MeSH Number(s) |
D12.776.543.750.100.700.700.300 D12.776.543.750.720.700.700.300
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| Concept/Terms |
Receptor, Adenosine A3- Receptor, Adenosine A3
- A3 Receptor, Adenosine
- Adenosine A3 Receptors
- A3 Receptors, Adenosine
- Receptors, Adenosine A3
- Adenosine A3 Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, Adenosine A3".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Purinergic [D12.776.543.750.100.700]
- Receptors, Purinergic P1 [D12.776.543.750.100.700.700]
- Receptor, Adenosine A3 [D12.776.543.750.100.700.700.300]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Purinergic [D12.776.543.750.720.700]
- Receptors, Purinergic P1 [D12.776.543.750.720.700.700]
- Receptor, Adenosine A3 [D12.776.543.750.720.700.700.300]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Adenosine A3".
This graph shows the total number of publications written about "Receptor, Adenosine A3" by people in this website by year, and whether "Receptor, Adenosine A3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 3 | 0 | 3 | | 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Receptor, Adenosine A3" by people in Profiles.
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Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24; 58(24):9578-90.
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Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 2015 Nov; 98:68-77.
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Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. Br J Pharmacol. 2014 Aug; 171(16):3827-44.
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Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB J. 2014 Oct; 28(10):4211-22.
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Hill SJ, May LT, Kellam B, Woolard J. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. Br J Pharmacol. 2014 Mar; 171(5):1102-13.
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Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep. 2013 Aug; 14(8):726-32.
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Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012 Sep 21; 19(9):1105-15.
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May LT, Bridge LJ, Stoddart LA, Briddon SJ, Hill SJ. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. FASEB J. 2011 Oct; 25(10):3465-76.
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May LT, Briddon SJ, Hill SJ. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Mol Pharmacol. 2010 Apr; 77(4):678-86.
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Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. FASEB J. 2008 Mar; 22(3):850-60.
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