 Methacholine Chloride
"Methacholine Chloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
| Descriptor ID |
D016210
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| MeSH Number(s) |
D02.092.877.883.555.500 D02.675.276.534.500
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| Concept/Terms |
Methacholine Chloride- Methacholine Chloride
- Chloride, Methacholine
- Mecholine
- Acetyl-beta-methacholine Chloride
- Acetyl beta methacholine Chloride
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
- Acetyl-2-methylcholine Chloride
- Acetyl 2 methylcholine Chloride
Provocholine- Provocholine
- Roche Brand of Methacholine Chloride
- Methapharma Brand of Methacholine Chloride
Provokit- Provokit
- Lindopharm Brand of Methacholine Chloride
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Below are MeSH descriptors whose meaning is more general than "Methacholine Chloride".
Below are MeSH descriptors whose meaning is more specific than "Methacholine Chloride".
This graph shows the total number of publications written about "Methacholine Chloride" by people in this website by year, and whether "Methacholine Chloride" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methacholine Chloride" by people in Profiles.
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Shardonofsky FR, Moore J, Schwartz RJ, Boriek AM. Airways in smooth muscle a-actin null mice experience a compensatory mechanism that modulates their contractile response. J Appl Physiol (1985). 2012 Mar; 112(5):898-903.
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Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40.
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Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA. Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther. 2008; 21(1):115-24.
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Kleis S, Chanez P, Delvaux M, Louis R. Perception of dyspnea in mild smoking asthmatics. Respir Med. 2007 Jul; 101(7):1426-30.
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Evans KL, Bond RA, Corry DB, Shardonofsky FR. Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma. J Appl Physiol (1985). 2003 Jan; 94(1):245-52.
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Harriss DR, Marsh KA, Birmingham AT, Hill SJ. Expression of muscarinic M3-receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. J Urol. 1995 Sep; 154(3):1241-5.
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Hall IP, Hill SJ. Effects of isozyme selective phosphodiesterase inhibitors on bovine tracheal smooth muscle tone. Biochem Pharmacol. 1992 Jan 09; 43(1):15-7.
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