 Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
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| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
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| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
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Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2004 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.
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Perez C, Ziburkus J, Ullah G. Analyzing and Modeling the Dysfunction of Inhibitory Neurons in Alzheimer's Disease. PLoS One. 2016; 11(12):e0168800.
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Han HJ, Allen CC, Buchovecky CM, Yetman MJ, Born HA, Marin MA, Rodgers SP, Song BJ, Lu HC, Justice MJ, Probst FJ, Jankowsky JL. Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. J Neurosci. 2012 Aug 01; 32(31):10574-86.
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Rodgers SP, Born HA, Das P, Jankowsky JL. Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult. Mol Neurodegener. 2012 Jun 18; 7:28.
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Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Anal Biochem. 2012 Feb 15; 421(2):467-76.
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Alkadhi KA, Alzoubi KH, Srivareerat M, Tran TT. Elevation of BACE in an Aß rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine. Int J Neuropsychopharmacol. 2012 Mar; 15(2):223-33.
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Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res. 2006 Jul; 3(3):221-7.
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Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):129-36.
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