 Caspases
"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
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| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 | | 2003 | 1 | 2 | 3 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 2 | 3 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspases" by people in Profiles.
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Pinan-Lucarre B, Gabel CV, Reina CP, Hulme SE, Shevkoplyas SS, Slone RD, Xue J, Qiao Y, Weisberg S, Roodhouse K, Sun L, Whitesides GM, Samuel A, Driscoll M. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS Biol. 2012; 10(5):e1001331.
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Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010 May 15; 88(7):1569-76.
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Johnke RM, Smith ES, Cariveau MJ, Evans MJ, Kilburn JM, Bakken NT, Nangami GN. Radioprotection of murine gastrointestinal epithelium by interleukin-1alpha involves down-regulation of the apoptotic response. Anticancer Res. 2008 Nov-Dec; 28(6A):3601-7.
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Garcia M, Konoplev S, Morosan C, Abruzzo LV, Bueso-Ramos CE, Medeiros LJ. MALT lymphoma involving the kidney: a report of 10 cases and review of the literature. Am J Clin Pathol. 2007 Sep; 128(3):464-73.
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Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19; 50(8):1886-95.
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Kanan Y, Moiseyev G, Agarwal N, Ma JX, Al-Ubaidi MR. Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):40-51.
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Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14495-500.
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Yeh LA, Padmanaban D, Ho P, Xing X, Rowley P, Morse LJ, Jensen RV, Cuny GD. Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Bioorg Med Chem Lett. 2005 Feb 15; 15(4):1193-6.
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West JD, Ji C, Marnett LJ. Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1. J Biol Chem. 2005 Apr 15; 280(15):15141-7.
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Baek KH, Shin HJ, Jeong SJ, Park JW, McKeon F, Lee CW, Kim CM. Caspases-dependent cleavage of mitotic checkpoint proteins in response to microtubule inhibitor. Oncol Res. 2005; 15(3):161-8.
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