 Small Molecule Libraries
"Small Molecule Libraries" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.
| Descriptor ID |
D054852
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| MeSH Number(s) |
D27.720.470.765
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| Concept/Terms |
Small Molecule Libraries- Small Molecule Libraries
- Libraries, Small Molecule
- Molecule Libraries, Small
- Molecular Libraries, Small
- Libraries, Small Molecular
- Small Molecular Libraries
- Chemical Libraries
- Libraries, Chemical
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Below are MeSH descriptors whose meaning is more general than "Small Molecule Libraries".
Below are MeSH descriptors whose meaning is more specific than "Small Molecule Libraries".
This graph shows the total number of publications written about "Small Molecule Libraries" by people in this website by year, and whether "Small Molecule Libraries" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2010 | 3 | 0 | 3 | | 2011 | 0 | 1 | 1 | | 2012 | 5 | 1 | 6 | | 2013 | 2 | 0 | 2 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Small Molecule Libraries" by people in Profiles.
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Schwehm C, Kellam B, Garces AE, Hill SJ, Kindon ND, Bradshaw TD, Li J, Macdonald SJ, Rowedder JE, Stoddart LA, Stocks MJ. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase d (PI3Kd) Inhibitors. J Med Chem. 2017 Feb 23; 60(4):1534-1554.
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Napoli M, Venkatanarayan A, Raulji P, Meyers BA, Norton W, Mangala LS, Sood AK, Rodriguez-Aguayo C, Lopez-Berestein G, Vin H, Duvic M, Tetzlaff MB, Curry JL, Rook AH, Abbas HA, Coarfa C, Gunaratne PH, Tsai KY, Flores ER. ?Np63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Cancer Cell. 2016 06 13; 29(6):874-888.
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Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24; 58(24):9578-90.
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Filgueira CS, Benod C, Lou X, Gunamalai PS, Villagomez RA, Strom A, Gustafsson JÅ, Berkenstam AL, Webb P. A screening cascade to identify ERß ligands. Nucl Recept Signal. 2014; 12:e003.
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Kathman SG, Xu Z, Statsyuk AV. A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem. 2014 Jun 12; 57(11):4969-74.
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De S, Chen L, Zhang S, Gilbertson SR. Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. ACS Comb Sci. 2013 Jul 08; 15(7):340-3.
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Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med. 2013 Jul; 5(7):1103-18.
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Schein CH, Chen D, Ma L, Kanalas JJ, Gao J, Jimenez ME, Sower LE, Walter MA, Gilbertson SR, Peterson JW. Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor. Toxins (Basel). 2012 Nov 08; 4(11):1288-300.
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Mallipeddi PL, Joshi M, Briggs JM. Pharmacophore-based virtual screening to aid in the identification of unknown protein function. Chem Biol Drug Des. 2012 Dec; 80(6):828-42.
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Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012 Sep 21; 19(9):1105-15.
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