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Institution

James West

TitleAssistant Professor, Instruct
InstitutionUniversity of Houston
DepartmentMathematics
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-3500
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    Collapse Research 
    Collapse research activities and funding
    R01HL071596     (FAGAN, KAREN A)Sep 19, 2003 - Jul 31, 2009
    NIH/NHLBI
    Effects of BMPRII Mutations in Pulmonary Hypertension
    Role: Co-Principal Investigator
    R21HL079315     (FAGAN, KAREN A)Jan 7, 2005 - Dec 31, 2007
    NIH/NHLBI
    Genetics of Pulmonary Hypertension in Mice
    Role: Co-Principal Investigator
    F32GM078965     (WEST, JAMES D)Jul 1, 2006 - Jun 30, 2008
    NIH/NIGMS
    Molecular Chaperone Regulation in Caenorhabditis elegans
    Role: Principal Investigator
    R01HL082694     (WEST, JAMES D)Sep 1, 2007 - Aug 31, 2012
    NIH/NHLBI
    Role of p38 and p42/44 MAPK in Pulmonary Arterial Hypertension
    Role: Principal Investigator
    R01HL095797     (WEST, JAMES D)Mar 31, 2009 - Nov 30, 2018
    NIH/NHLBI
    Interventions Against the Molecular Etiology of BMPR2-induced PAH
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pickworth J, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey PM, Gladson S, Shay S, Morrell NW, Francis SE, West JD, Lawrie A. Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling. Pulm Circ. 2017 Sep 22; 2045893217729096. PMID: 28828907.
      View in: PubMed
    2. Suzuki T, Carrier EJ, Talati MA, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West JD. Isolation and characterization of endothelial-to-mesenchymal transition-cells in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 21; ajplung.00296.2017. PMID: 28935639.
      View in: PubMed
    3. Copeland CA, Han B, Tiwari A, Austin ED, Loyd JE, West JD, Kenworthy AK. A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal. Mol Biol Cell. 2017 Sep 13. PMID: 28904206.
      View in: PubMed
    4. Trammell AW, Talati M, Blackwell TR, Fortune NL, Niswender KD, Fessel JP, Newman JH, West JD, Hemnes AR. Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension. Pulm Circ. 2017 Jul-Sep; 7(3):624-634. PMID: 28704134.
      View in: PubMed
    5. Chen X, Austin ED, Talati M, Fessel JP, Farber-Eger EH, Brittain EL, Hemnes AR, Loyd JE, West J. Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects. Eur Respir J. 2017 Aug; 50(2). PMID: 28775043.
      View in: PubMed
    6. Sakurai-Iesato Y, Kawata N, Tada Y, Iesato K, Matsuura Y, Yahaba M, Suzuki T, Ikari J, Yanagawa N, Kasahara Y, West J, Tatsumi K. The Relationship of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease Classified According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Combined Chronic Obstructive Pulmonary Disease (COPD) Assessment System. Intern Med. 2017; 56(14):1781-1790. PMID: 28717072.
      View in: PubMed
    7. Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J Clin Invest. 2017 Jun 01; 127(6):2262-2276. PMID: 28463231.
      View in: PubMed
    8. Nickel NP, O'Leary JM, Brittain EL, Fessel JP, Zamanian RT, West JD, Austin ED. Kidney dysfunction in patients with pulmonary arterial hypertension. Pulm Circ. 2017 Mar; 7(1):38-54. PMID: 28680564.
      View in: PubMed
    9. Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ, Hemnes AR, West J, Fessel JP. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulm Circ. 2017 Mar; 7(1):186-199. PMID: 28680578.
      View in: PubMed
    10. Austin ED, West J, Loyd JE, Hemnes AR. Translational Advances in the Field of Pulmonary Hypertension Molecular Medicine of Pulmonary Arterial Hypertension. From Population Genetics to Precision Medicine and Gene Editing. Am J Respir Crit Care Med. 2017 Jan 01; 195(1):23-31. PMID: 27398627.
      View in: PubMed
    11. Frump AL, Datta A, Ghose S, West J, de Caestecker MP. Genotype-phenotype effects of Bmpr2 mutations on disease severity in mouse models of pulmonary hypertension. Pulm Circ. 2016 Dec; 6(4):597-607. PMID: 28090303.
      View in: PubMed
    12. Allan KM, Loberg MA, Chepngeno J, Hurtig JE, Tripathi S, Kang MG, Allotey JK, Widdershins AH, Pilat JM, Sizek HJ, Murphy WJ, Naticchia MR, David JB, Morano KA, West JD. Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker. Free Radic Biol Med. 2016 Dec; 101:356-366. PMID: 27816612.
      View in: PubMed
    13. Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle. Am J Respir Crit Care Med. 2016 Sep 15; 194(6):719-28. PMID: 27077479; PMCID: PMC5027228 [Available on 09/15/17].
      View in: PubMed, PubMed Central
    14. Awad KS, West JD, de Jesus Perez V, MacLean M. Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulm Circ. 2016 Sep; 6(3):285-94. PMID: 27683605.
      View in: PubMed
    15. Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 Aug 15; 194(4):464-75. PMID: 26926454; PMCID: PMC5003329 [Available on 08/15/17].
      View in: PubMed, PubMed Central
    16. Nguyen TT, Caito SW, Zackert WE, West JD, Zhu S, Aschner M, Fessel JP, Roberts LJ. Scavengers of reactive ?-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging (Albany NY). 2016 Aug; 8(8):1759-80. PMID: 27514077.
      View in: PubMed
    17. Yan L, West J, Hamid R. Reply: Expanded Role for Bone Marrow-derived Hematopoietic Stem and Progenitor Cells in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 Aug 01; 194(3):384-5. PMID: 27479065; PMCID: PMC4970599 [Available on 08/01/17].
      View in: PubMed, PubMed Central
    18. West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. Pulm Circ. 2016 Jun; 6(2):211-23. PMID: 27252848; PMCID: PMC4869926.
      View in: PubMed, PubMed Central
    19. Correa DD, Wang Y, West JD, Peck KK, Root JC, Baser RE, Thaler HT, Shore TB, Jakubowski A, Saykin AJ, Relkin N. Prospective assessment of white matter integrity in adult stem cell transplant recipients. Brain Imaging Behav. 2016 Jun; 10(2):486-96. PMID: 26153467; PMCID: PMC4706509 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    20. Suzuki T, Tada Y, Nishimura R, Kawasaki T, Sekine A, Urushibara T, Kato F, Kinoshita T, Ikari J, West J, Tatsumi K. Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 01; 310(11):L1185-98. PMID: 27106288.
      View in: PubMed
    21. Yan L, Chen X, Talati M, Nunley BW, Gladson S, Blackwell T, Cogan J, Austin E, Wheeler F, Loyd J, West J, Hamid R. Bone Marrow-derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 Apr 15; 193(8):898-909. PMID: 26651104; PMCID: PMC4849178 [Available on 04/15/17].
      View in: PubMed, PubMed Central
    22. West J, Gill WW. Genome Editing in Large Animals. J Equine Vet Sci. 2016 Jun; 41:1-6. PMID: 27766006.
      View in: PubMed
    23. Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation. 2016 May 17; 133(20):1936-44. PMID: 27006481; PMCID: PMC4870107 [Available on 05/17/17].
      View in: PubMed, PubMed Central
    24. West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD. Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension. PLoS One. 2016; 11(2):e0148657. PMID: 26863209; PMCID: PMC4749293.
      View in: PubMed, PubMed Central
    25. Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 01; 310(3):L249-62. PMID: 26637636; PMCID: PMC4838140 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    26. Fessel JP, West JD. Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series). Pulm Circ. 2015 Dec; 5(4):599-609. PMID: 26697167; PMCID: PMC4671734.
      View in: PubMed, PubMed Central
    27. Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD. Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Pulm Circ. 2015 Dec; 5(4):681-90. PMID: 26697175; PMCID: PMC4671742.
      View in: PubMed, PubMed Central
    28. Huang J, Wolk JH, Gewitz MH, Loyd JE, West J, Austin ED, Mathew R. Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation. World J Cardiol. 2015 Oct 26; 7(10):671-84. PMID: 26516422; PMCID: PMC4620079.
      View in: PubMed, PubMed Central
    29. Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED. Estrogen Metabolite 16a-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism. Circulation. 2016 Jan 05; 133(1):82-97. PMID: 26487756; PMCID: PMC4698046 [Available on 01/05/17].
      View in: PubMed, PubMed Central
    30. West JD, Cheetham TD, Dane C, Natarajan A. Should radioiodine be the first-line treatment for paediatric Graves' disease? J Pediatr Endocrinol Metab. 2015 Jul; 28(7-8):797-804. PMID: 25719296.
      View in: PubMed
    31. Suzuki T, Tada Y, Kawata N, Ikari J, Kasahara Y, Sakurai Y, Iesato K, Nishimura R, West J, Tatsumi K. Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document. Int J Chron Obstruct Pulmon Dis. 2015; 10:1199-205. PMID: 26150711; PMCID: PMC4480590.
      View in: PubMed, PubMed Central
    32. Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015 Apr 15; 6:6863. PMID: 25873470; PMCID: PMC4399003.
      View in: PubMed, PubMed Central
    33. Bloodworth NC, West JD, Merryman WD. Microvessel mechanobiology in pulmonary arterial hypertension: cause and effect. Hypertension. 2015 Mar; 65(3):483-9. PMID: 25534705; PMCID: PMC4326545.
      View in: PubMed, PubMed Central
    34. Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation. 2015 Jan 27; 131(4):401-9; discussion 409. PMID: 25361553; PMCID: PMC4308423.
      View in: PubMed, PubMed Central
    35. Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol. 2014 Oct 15; 307(8):C684-98. PMID: 25122876; PMCID: PMC4200000.
      View in: PubMed, PubMed Central
    36. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug; 124(8):3514-28. PMID: 24960162; PMCID: PMC4109523.
      View in: PubMed, PubMed Central
    37. Ellington LE, Emmanouilidou D, Elhilali M, Gilman RH, Tielsch JM, Chavez MA, Marin-Concha J, Figueroa D, West J, Checkley W. Developing a reference of normal lung sounds in healthy Peruvian children. Lung. 2014 Oct; 192(5):765-73. PMID: 24943262.
      View in: PubMed
    38. West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Sep 01; 307(5):C415-30. PMID: 24871858; PMCID: PMC4154073.
      View in: PubMed, PubMed Central
    39. West J, Austin E, Fessel JP, Loyd J, Hamid R. Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension. Drug Discov Today. 2014 Aug; 19(8):1241-5. PMID: 24794464; PMCID: PMC4396626.
      View in: PubMed, PubMed Central
    40. Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K. BMP pathway regulation of and by macrophages. PLoS One. 2014; 9(4):e94119. PMID: 24713633; PMCID: PMC3979749.
      View in: PubMed, PubMed Central
    41. Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J. Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):325-34. PMID: 24274756; PMCID: PMC3977729.
      View in: PubMed, PubMed Central
    42. Fessel JP, Chen X, Frump A, Gladson S, Blackwell T, Kang C, Johnson J, Loyd JE, Hemnes A, Austin E, West J. Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension. Pulm Circ. 2013 Sep; 3(3):564-77. PMID: 24618541; PMCID: PMC4070799.
      View in: PubMed, PubMed Central
    43. Brittain E, Penner NL, West J, Hemnes A. Echocardiographic assessment of the right heart in mice. J Vis Exp. 2013 Nov 27; (81). PMID: 24326586; PMCID: PMC3992116.
      View in: PubMed, PubMed Central
    44. Spencer MK, Radzinski NP, Tripathi S, Chowdhury S, Herrin RP, Chandran NN, Daniel AK, West JD. Pronounced toxicity differences between homobifunctional protein cross-linkers and analogous monofunctional electrophiles. Chem Res Toxicol. 2013 Nov 18; 26(11):1720-9. PMID: 24138115.
      View in: PubMed
    45. Fessel JP, Flynn CR, Robinson LJ, Penner NL, Gladson S, Kang CJ, Wasserman DH, Hemnes AR, West JD. Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Nov; 49(5):778-87. PMID: 23742019; PMCID: PMC3931097.
      View in: PubMed, PubMed Central
    46. Cianciolo Cosentino C, Skrypnyk NI, Brilli LL, Chiba T, Novitskaya T, Woods C, West J, Korotchenko VN, McDermott L, Day BW, Davidson AJ, Harris RC, de Caestecker MP, Hukriede NA. Histone deacetylase inhibitor enhances recovery after AKI. J Am Soc Nephrol. 2013 May; 24(6):943-53. PMID: 23620402; PMCID: PMC3665399.
      View in: PubMed, PubMed Central
    47. Das M, Fessel J, West J. Author's Reply. Pulm Circ. 2013 Apr; 3(2):447-8. PMID: 24015350; PMCID: PMC3757845.
      View in: PubMed, PubMed Central
    48. Austin ED, Lahm T, West J, Tofovic SP, Johansen AK, Maclean MR, Alzoubi A, Oka M. Gender, sex hormones and pulmonary hypertension. Pulm Circ. 2013 Apr; 3(2):294-314. PMID: 24015330; PMCID: PMC3757824.
      View in: PubMed, PubMed Central
    49. Naticchia MR, Brown HA, Garcia FJ, Lamade AM, Justice SL, Herrin RP, Morano KA, West JD. Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells. Chem Res Toxicol. 2013 Mar 18; 26(3):490-7. PMID: 23414292; PMCID: PMC3637938.
      View in: PubMed, PubMed Central
    50. Park SH, Chen WC, Hoffman C, Marsh LM, West J, Grunig G. Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene. PLoS One. 2013; 8(1):e55180. PMID: 23383100; PMCID: PMC3558423.
      View in: PubMed, PubMed Central
    51. Chen WC, Park SH, Hoffman C, Philip C, Robinson L, West J, Grunig G. Right ventricular systolic pressure measurements in combination with harvest of lung and immune tissue samples in mice. J Vis Exp. 2013 Jan 16; (71):e50023. PMID: 23354416; PMCID: PMC3582655.
      View in: PubMed, PubMed Central
    52. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173; PMCID: PMC3641738.
      View in: PubMed, PubMed Central
    53. Das M, Fessel J, Tang H, West J. A process-based review of mouse models of pulmonary hypertension. Pulm Circ. 2012 Oct; 2(4):415-33. PMID: 23372926; PMCID: PMC3555412.
      View in: PubMed, PubMed Central
    54. West J, Niswender KD, Johnson JA, Pugh ME, Gleaves L, Fessel JP, Hemnes AR. A potential role for insulin resistance in experimental pulmonary hypertension. Eur Respir J. 2013 Apr; 41(4):861-71. PMID: 22936709; PMCID: PMC3746982.
      View in: PubMed, PubMed Central
    55. Cogan J, Austin E, Hedges L, Womack B, West J, Loyd J, Hamid R. Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance. Circulation. 2012 Oct 09; 126(15):1907-16. PMID: 22923426; PMCID: PMC4113011.
      View in: PubMed, PubMed Central
    56. Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Nov 01; 186(9):892-6. PMID: 22923661; PMCID: PMC3530218.
      View in: PubMed, PubMed Central
    57. West JD, Wang Y, Morano KA. Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol. 2012 Oct 15; 25(10):2036-53. PMID: 22799889; PMCID: PMC3472121.
      View in: PubMed, PubMed Central
    58. Wang Y, Gibney PA, West JD, Morano KA. The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds. Mol Biol Cell. 2012 Sep; 23(17):3290-8. PMID: 22809627; PMCID: PMC3469052.
      View in: PubMed, PubMed Central
    59. Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH. Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ. 2012 Jul; 2(3):352-8. PMID: 23130103; PMCID: PMC3487303.
      View in: PubMed, PubMed Central
    60. Shigeta A, Tada Y, Wang JY, Ishizaki S, Tsuyusaki J, Yamauchi K, Kasahara Y, Iesato K, Tanabe N, Takiguchi Y, Sakamoto A, Tokuhisa T, Shibuya K, Hiroshima K, West J, Tatsumi K. CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L141-51. PMID: 22610351.
      View in: PubMed
    61. Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet. 2012 Jun; 5(3):336-43. PMID: 22474227; PMCID: PMC3380156.
      View in: PubMed, PubMed Central
    62. Fessel JP, Hamid R, Wittmann BM, Robinson LJ, Blackwell T, Tada Y, Tanabe N, Tatsumi K, Hemnes AR, West JD. Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ. 2012 Apr-Jun; 2(2):201-13. PMID: 22837861; PMCID: PMC3401874.
      View in: PubMed, PubMed Central
    63. Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR. The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J. 2012 Jun; 26(6):2546-57. PMID: 22415303; PMCID: PMC3650483.
      View in: PubMed, PubMed Central
    64. Austin ED, Hamid R, Hemnes AR, Loyd JE, Blackwell T, Yu C, Phillips Iii JA, Gaddipati R, Gladson S, Gu E, West J, Lane KB. BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ. 2012 Feb 20; 3(1):6. PMID: 22348410; PMCID: PMC3310853.
      View in: PubMed, PubMed Central
    65. Flynn C, Zheng S, Yan L, Hedges L, Womack B, Fessel J, Cogan J, Austin E, Loyd J, West J, Zhao Z, Hamid R. Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance. Am J Respir Cell Mol Biol. 2012 Jul; 47(1):20-7. PMID: 22312021; PMCID: PMC3402799.
      View in: PubMed, PubMed Central
    66. Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 01; 302(5):L474-84. PMID: 22180660; PMCID: PMC3311512.
      View in: PubMed, PubMed Central
    67. Yasuda T, Tada Y, Tanabe N, Tatsumi K, West J. Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L667-74. PMID: 21856816; PMCID: PMC3774329.
      View in: PubMed, PubMed Central
    68. West JD, Stamm CE, Brown HA, Justice SL, Morano KA. Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chem Res Toxicol. 2011 Sep 19; 24(9):1457-9. PMID: 21812477.
      View in: PubMed
    69. Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul-Sep; 1(3):389-98. PMID: 22140629; PMCID: PMC3224431.
      View in: PubMed, PubMed Central
    70. Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res. 2011 Jun 22; 12:84. PMID: 21696628; PMCID: PMC3141420.
      View in: PubMed, PubMed Central
    71. Johnson JA, West J, Maynard KB, Hemnes AR. ACE2 improves right ventricular function in a pressure overload model. PLoS One. 2011; 6(6):e20828. PMID: 21695173; PMCID: PMC3112229.
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    72. Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL. Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2814-9. PMID: 21576484; PMCID: PMC3286911.
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    73. Nagayoshi M, Tada Y, West J, Ochiai E, Watanabe A, Toyotome T, Tanabe N, Takiguchi Y, Shigeta A, Yasuda T, Shibuya K, Kamei K, Tatsumi K. Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. Mycopathologia. 2011 Jul; 172(1):5-15. PMID: 21505873.
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    74. Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant. 2011 Aug; 30(8):904-11. PMID: 21493097; PMCID: PMC3129440.
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    75. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr; 29(4):725-35. PMID: 21312316; PMCID: PMC3322548.
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    76. West J, Hemnes A. Experimental and transgenic models of pulmonary hypertension. Compr Physiol. 2011 Apr; 1(2):769-82. PMID: 23737202.
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    77. Lane KL, Talati M, Austin E, Hemnes AR, Johnson JA, Fessel JP, Blackwell T, Mernaugh RL, Robinson L, Fike C, Roberts LJ, West J. Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ. 2011; 1(1):72-83. PMID: 21904662.
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    78. West JD, Stamm CE, Kingsley PJ. Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent. Chem Res Toxicol. 2011 Jan 14; 24(1):81-8. PMID: 21105742.
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    79. West J. Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension. Adv Exp Med Biol. 2010; 661:265-78. PMID: 20204736.
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    80. Johnson JA, Vnencak-Jones CL, Cogan JD, Loyd JE, West J. Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension. BMC Med Genet. 2009 Jun 16; 10:58. PMID: 19531247; PMCID: PMC2706815.
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    81. Crona D, Harral J, Adnot S, Eddahibi S, West J. Gene expression in lungs of mice lacking the 5-hydroxytryptamine transporter gene. BMC Pulm Med. 2009 May 10; 9:19. PMID: 19426553; PMCID: PMC2688484.
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    82. Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, Wheeler LA, Parl FF, Loyd JE, Phillips JA. Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur Respir J. 2009 Nov; 34(5):1093-9. PMID: 19357154; PMCID: PMC3742124.
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    83. West J, Cogan J, Geraci M, Robinson L, Newman J, Phillips JA, Lane K, Meyrick B, Loyd J. Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance. BMC Med Genomics. 2008 Sep 29; 1:45. PMID: 18823550; PMCID: PMC2561034.
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    84. West J, Harral J, Lane K, Deng Y, Ickes B, Crona D, Albu S, Stewart D, Fagan K. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L744-55. PMID: 18723761; PMCID: PMC2584890.
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    85. Saavedra MT, Hughes GJ, Sanders LA, Carr M, Rodman DM, Coldren CD, Geraci MW, Sagel SD, Accurso FJ, West J, Nick JA. Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):929-38. PMID: 18723435; PMCID: PMC2577728.
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    86. Tada Y, Laudi S, Harral J, Carr M, Ivester C, Tanabe N, Takiguchi Y, Tatsumi K, Kuriyama T, Nichols WC, West J. Murine pulmonary response to chronic hypoxia is strain specific. Exp Lung Res. 2008 Aug; 34(6):313-23. PMID: 18600498; PMCID: PMC3769701.
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    87. Saavedra MT, Patterson AD, West J, Randell SH, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):679-88. PMID: 18218994; PMCID: PMC2396247.
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    88. Trott A, West JD, Klaic L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell. 2008 Mar; 19(3):1104-12. PMID: 18199679; PMCID: PMC2262981.
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    89. Laudi S, Trump S, Schmitz V, West J, McMurtry IF, Mutlak H, Christians U, Weimann J, Kaisers U, Steudel W. Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L630-8. PMID: 17575010.
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    90. Tada Y, Majka S, Carr M, Harral J, Crona D, Kuriyama T, West J. Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1556-63. PMID: 17369292.
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    91. Hagen M, Fagan K, Steudel W, Carr M, Lane K, Rodman DM, West J. Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1473-9. PMID: 17322283.
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    92. Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Circ Res. 2006 Mar 31; 98(6):846-55. PMID: 16484612.
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    93. West JD, Marnett LJ. Endogenous reactive intermediates as modulators of cell signaling and cell death. Chem Res Toxicol. 2006 Feb; 19(2):173-94. PMID: 16485894.
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    94. Young KA, Ivester C, West J, Carr M, Rodman DM. BMP signaling controls PASMC KV channel expression in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2006 May; 290(5):L841-8. PMID: 16339782.
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    95. West J, Tada Y, Fagan KA, Steudel W, Fouty BW, Harral JW, Miller M, Ozimek J, Tuder RM, Rodman DM. Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic mice. Chest. 2005 Dec; 128(6 Suppl):553S. PMID: 16373822.
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    96. Golembeski SM, West J, Tada Y, Fagan KA. Interleukin-6 causes mild pulmonary hypertension and augments hypoxia-induced pulmonary hypertension in mice. Chest. 2005 Dec; 128(6 Suppl):572S-573S. PMID: 16373831.
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    97. West JD, Marnett LJ. Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. Chem Res Toxicol. 2005 Nov; 18(11):1642-53. PMID: 16300372.
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    98. Rodman DM, Reese K, Harral J, Fouty B, Wu S, West J, Hoedt-Miller M, Tada Y, Li KX, Cool C, Fagan K, Cribbs L. Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res. 2005 Apr 29; 96(8):864-72. PMID: 15774856.
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    99. West JD, Ji C, Marnett LJ. Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1. J Biol Chem. 2005 Apr 15; 280(15):15141-7. PMID: 15703174.
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    100. Lu X, Arbiser JL, West J, Hoedt-Miller M, Sheridan A, Govindarajan B, Harral JW, Rodman DM, Fouty B. Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells. Am J Pathol. 2004 Nov; 165(5):1613-20. PMID: 15509531; PMCID: PMC1618658.
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    101. West J, Buchholz M, Fiero A, Tada Y, Fagan K, Rodman D. Adenoviral gene transfer to the neonatal rat pulmonary circulation. J Gene Med. 2004 Jul; 6(7):734-9. PMID: 15241780.
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    102. West JD, Ji C, Duncan ST, Amarnath V, Schneider C, Rizzo CJ, Brash AR, Marnett LJ. Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation. Chem Res Toxicol. 2004 Apr; 17(4):453-62. PMID: 15089087.
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    103. West J, Fagan K, Steudel W, Fouty B, Lane K, Harral J, Hoedt-Miller M, Tada Y, Ozimek J, Tuder R, Rodman DM. Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res. 2004 Apr 30; 94(8):1109-14. PMID: 15031260.
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    104. Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J Clin Invest. 2003 Mar; 111(5):583-93. PMID: 12618510; PMCID: PMC151910.
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    105. Saavedra M, Vasil M, Randell S, West J, Rodman D. Pseudomonas aeruginosa-human airway epithelial cell interaction: effects of iron on inflammation and apoptosis. Chest. 2002 Mar; 121(3 Suppl):40S-41S. PMID: 11893679.
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    106. Borthwick DW, West JD, Keighren MA, Flockhart JH, Innes BA, Dorin JR. Murine submucosal glands are clonally derived and show a cystic fibrosis gene-dependent distribution pattern. Am J Respir Cell Mol Biol. 1999 Jun; 20(6):1181-9. PMID: 10340937.
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    107. Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9572-7. PMID: 9689122; PMCID: PMC21380.
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