 Clozapine
"Clozapine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
| Descriptor ID |
D003024
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| MeSH Number(s) |
D03.494.240.220
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Clozapine".
Below are MeSH descriptors whose meaning is more specific than "Clozapine".
This graph shows the total number of publications written about "Clozapine" by people in this website by year, and whether "Clozapine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clozapine" by people in Profiles.
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Tsekou H, Angelopoulos E, Paparrigopoulos T, Golemati S, Soldatos CR, Papadimitriou GN, Ktonas PY. Sleep EEG and spindle characteristics after combination treatment with clozapine in drug-resistant schizophrenia: a pilot study. J Clin Neurophysiol. 2015 Apr; 32(2):159-63.
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Qi LY, Xiu MH, Chen DC, Wang F, Kosten TA, Kosten TR, Zhang XY. Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. Neurosci Lett. 2009 Sep 22; 462(2):113-7.
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Chen DC, Qi LY, Xiu MH, Cao LY, Wang F, Chen S, Wu GY, Kosten TA, Kosten TR, Zhang XY. Elevated serum levels of tumor necrosis factor-alpha in clozapine-associated obesity in chronic schizophrenia. Schizophr Res. 2008 Dec; 106(2-3):367-8.
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Zhang XY, Cao LY, Song C, Wu GY, Chen DC, Qi LY, Wang F, Xiu MH, Chen S, Zhang Y, Lu L, Kosten TA, Kosten TR. Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics. Psychopharmacology (Berl). 2008 Dec; 201(3):383-9.
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Zhang XY, Tan YL, Zhou DF, Haile CN, Cao LY, Xu Q, Shen Y, Kosten TA, Kosten TR. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol. 2007 Jun; 27(3):246-51.
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Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Xu Q, Shen Y, Haile CN, Kosten TA, Kosten TR. Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. J Psychiatr Res. 2007 Dec; 41(12):997-1004.
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Farren CK, Hameedi FA, Rosen MA, Woods S, Jatlow P, Kosten TR. Significant interaction between clozapine and cocaine in cocaine addicts. Drug Alcohol Depend. 2000 May 01; 59(2):153-63.
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Schafer JA, Li L, Sun D. The collecting duct, dopamine and vasopressin-dependent hypertension. Acta Physiol Scand. 2000 Jan; 168(1):239-44.
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Li L, Schafer JA. Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct. Am J Physiol. 1998 Jul; 275(1 Pt 2):F62-7.
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Kosten TA, Nestler EJ. Clozapine attenuates cocaine conditioned place preference. Life Sci. 1994; 55(1):PL9-14.
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