 Thioredoxins
"Thioredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.
| Descriptor ID |
D013879
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| MeSH Number(s) |
D12.776.915
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thioredoxins".
Below are MeSH descriptors whose meaning is more specific than "Thioredoxins".
This graph shows the total number of publications written about "Thioredoxins" by people in this website by year, and whether "Thioredoxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 2 | 0 | 2 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thioredoxins" by people in Profiles.
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Chen C, Chen H, Zhou HJ, Ji W, Min W. Mechanistic Role of Thioredoxin 2 in Heart Failure. Adv Exp Med Biol. 2017; 982:265-276.
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Huang Q, Zhou HJ, Zhang H, Huang Y, Hinojosa-Kirschenbaum F, Fan P, Yao L, Belardinelli L, Tellides G, Giordano FJ, Budas GR, Min W. Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function. Circulation. 2015 Mar 24; 131(12):1082-97.
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Abais JM, Xia M, Li G, Chen Y, Conley SM, Gehr TW, Boini KM, Li PL. Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia. J Biol Chem. 2014 Sep 26; 289(39):27159-68.
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Ji W, Yang M, Praggastis A, Li Y, Zhou HJ, He Y, Ghazvinian R, Cincotta DJ, Rice KP, Min W. Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. PLoS One. 2014; 9(7):e103224.
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Spencer MK, Radzinski NP, Tripathi S, Chowdhury S, Herrin RP, Chandran NN, Daniel AK, West JD. Pronounced toxicity differences between homobifunctional protein cross-linkers and analogous monofunctional electrophiles. Chem Res Toxicol. 2013 Nov 18; 26(11):1720-9.
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Naticchia MR, Brown HA, Garcia FJ, Lamade AM, Justice SL, Herrin RP, Morano KA, West JD. Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells. Chem Res Toxicol. 2013 Mar 18; 26(3):490-7.
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Zhang XY, Chen DC, Xiu MH, Yang FD, Tan YL, He S, Kosten TA, Kosten TR. Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls. Schizophr Res. 2013 Feb; 143(2-3):301-6.
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Min W, Xu LK, Zhou HJ, Huang Q, Zhang H, He Y, Zhe X, Luo Y. Thioredoxin and redox signaling in vasculature-studies using Trx2 endothelium-specific transgenic mice. Methods Enzymol. 2010; 474:315-24.
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Zhang XY, Chen DC, Xiu MH, Wang F, Qi LY, Sun HQ, Chen S, He SC, Wu GY, Haile CN, Kosten TA, Lu L, Kosten TR. The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients. Schizophr Res. 2009 Sep; 113(2-3):151-7.
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Fazelinia H, Cirino PC, Maranas CD. OptGraft: A computational procedure for transferring a binding site onto an existing protein scaffold. Protein Sci. 2009 Jan; 18(1):180-95.
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