Receptors, Cytoplasmic and Nuclear
"Receptors, Cytoplasmic and Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Descriptor ID |
D018160
|
MeSH Number(s) |
D12.776.826
|
Concept/Terms |
Receptors, Cytoplasmic and Nuclear- Receptors, Cytoplasmic and Nuclear
- Receptors, Cytosol and Nuclear
- Cytosolic and Nuclear Receptors
- Receptors, Nuclear and Cytoplasmic
- Cytoplasmic and Nuclear Receptors
- Cytosol and Nuclear Receptors
- Nuclear and Cytoplasmic Receptors
- Receptors, Cytosolic and Nuclear
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Cytoplasmic and Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Cytoplasmic and Nuclear".
This graph shows the total number of publications written about "Receptors, Cytoplasmic and Nuclear" by people in this website by year, and whether "Receptors, Cytoplasmic and Nuclear" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
---|
1995 | 2 | 0 | 2 | 1999 | 1 | 0 | 1 | 2002 | 3 | 0 | 3 | 2003 | 3 | 0 | 3 | 2004 | 1 | 0 | 1 | 2005 | 0 | 1 | 1 | 2006 | 1 | 1 | 2 | 2008 | 3 | 0 | 3 | 2009 | 3 | 0 | 3 | 2010 | 1 | 0 | 1 | 2012 | 0 | 1 | 1 | 2015 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Cytoplasmic and Nuclear" by people in Profiles.
-
Umetani M. Re-adopting classical nuclear receptors by cholesterol metabolites. J Steroid Biochem Mol Biol. 2016 Mar; 157:20-6.
-
Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, Simpson RJ, Moritz RL, Jane SM, Zhao Q. The role of WDR5 in silencing human fetal globin gene expression. Haematologica. 2012 Nov; 97(11):1632-40.
-
Lundquist JT, Harnish DC, Kim CY, Mehlmann JF, Unwalla RJ, Phipps KM, Crawley ML, Commons T, Green DM, Xu W, Hum WT, Eta JE, Feingold I, Patel V, Evans MJ, Lai K, Borges-Marcucci L, Mahaney PE, Wrobel JE. Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates. J Med Chem. 2010 Feb 25; 53(4):1774-87.
-
Mehlmann JF, Crawley ML, Lundquist JT, Unwalla RJ, Harnish DC, Evans MJ, Kim CY, Wrobel JE, Mahaney PE. Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR). Bioorg Med Chem Lett. 2009 Sep 15; 19(18):5289-92.
-
Hartman HB, Gardell SJ, Petucci CJ, Wang S, Krueger JA, Evans MJ. Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice. J Lipid Res. 2009 Jun; 50(6):1090-100.
-
Evans MJ, Mahaney PE, Borges-Marcucci L, Lai K, Wang S, Krueger JA, Gardell SJ, Huard C, Martinez R, Vlasuk GP, Harnish DC. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am J Physiol Gastrointest Liver Physiol. 2009 Mar; 296(3):G543-52.
-
Wrobel J, Steffan R, Bowen SM, Magolda R, Matelan E, Unwalla R, Basso M, Clerin V, Gardell SJ, Nambi P, Quinet E, Reminick JI, Vlasuk GP, Wang S, Feingold I, Huselton C, Bonn T, Farnegardh M, Hansson T, Nilsson AG, Wilhelmsson A, Zamaratski E, Evans MJ. Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. J Med Chem. 2008 Nov 27; 51(22):7161-8.
-
DiBlasio-Smith EA, Arai M, Quinet EM, Evans MJ, Kornaga T, Basso MD, Chen L, Feingold I, Halpern AR, Liu QY, Nambi P, Savio D, Wang S, Mounts WM, Isler JA, Slager AM, Burczynski ME, Dorner AJ, LaVallie ER. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J Transl Med. 2008 Oct 16; 6:59.
-
Hartman HB, Lai K, Evans MJ. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res. 2009 Feb; 50(2):193-203.
-
Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22; 281(38):27816-26.
|
People People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|