 1-Methyl-3-isobutylxanthine
"1-Methyl-3-isobutylxanthine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
| Descriptor ID |
D015056
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| MeSH Number(s) |
D03.438.759.758.824.751.500
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| Concept/Terms |
1-Methyl-3-isobutylxanthine- 1-Methyl-3-isobutylxanthine
- 1 Methyl 3 isobutylxanthine
- IBMX
- Isobutyltheophylline
- 3-Isobutyl-1-methylxanthine
- 3 Isobutyl 1 methylxanthine
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Below are MeSH descriptors whose meaning is more general than "1-Methyl-3-isobutylxanthine".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-3-isobutylxanthine".
This graph shows the total number of publications written about "1-Methyl-3-isobutylxanthine" by people in this website by year, and whether "1-Methyl-3-isobutylxanthine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 0 | 1 | 1 | | 1989 | 1 | 2 | 3 | | 1990 | 0 | 3 | 3 | | 1994 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "1-Methyl-3-isobutylxanthine" by people in Profiles.
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Reiser MA, D'Souza T, Dryer SE. Effects of caffeine and 3-isobutyl-1-methylxanthine on voltage-activated potassium currents in vertebrate neurones and secretory cells. Br J Pharmacol. 1996 Aug; 118(8):2145-51.
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D'Souza T, Dryer SE. Effects of phosphodiesterase inhibitors and forskolin on cyclic GMP-activated channels in intact isolated cells of the chick pineal gland. Neurochem Int. 1995 Dec; 27(6):527-33.
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Sakamoto T, Chen C, Lokhandwala MF. Attenuation of adenylate cyclase-induced increases in renal sodium excretion by the dopamine D-2 receptor agonist SK&F 89124. J Auton Pharmacol. 1994 Aug; 14(4):295-306.
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Schafer JA, Troutman SL. cAMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin. Am J Physiol. 1990 Nov; 259(5 Pt 2):F823-31.
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Hall IP, Donaldson J, Hill SJ. Modulation of fluoroaluminate-induced inositol phosphate formation by increases in tissue cyclic AMP content in bovine tracheal smooth muscle. Br J Pharmacol. 1990 Jul; 100(3):646-50.
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Hall IP, Donaldson J, Hill SJ. Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors. Biochem Pharmacol. 1990 Apr 15; 39(8):1357-63.
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Hall IP, Hill SJ. Inhibition by salbutamol, forskolin and IBMX of AlF4-induced inositol phosphate formation in bovine airway smooth muscle. Br J Pharmacol. 1989 Dec; 98 Suppl:788P.
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Alexander SP, Kendall DA, Hill SJ. Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex. Br J Pharmacol. 1989 Dec; 98(4):1241-8.
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Stanley C, Brown AM, Hill SJ. Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus. J Neurochem. 1989 Mar; 52(3):671-6.
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Hegde SS, Lokhandwala MF. Involvement of cyclic-AMP in the hypotensive response to fenoldopam but not to quinpirole in the anaesthetized rat. J Auton Pharmacol. 1988 Mar; 8(1):63-8.
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