 Gene Dosage
"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
| Descriptor ID |
D018628
|
| MeSH Number(s) |
G05.380.350
|
| Concept/Terms |
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
|
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in this website by year, and whether "Gene Dosage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2009 | 2 | 3 | 5 | | 2012 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Gene Dosage" by people in Profiles.
-
Orhan E, Dalkara D, Neuillé M, Lechauve C, Michiels C, Picaud S, Léveillard T, Sahel JA, Naash MI, Lavail MM, Zeitz C, Audo I. Genotypic and phenotypic characterization of P23H line 1 rat model. PLoS One. 2015; 10(5):e0127319.
-
Skretas G, Makino T, Varadarajan N, Pogson M, Georgiou G. Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli. Metab Eng. 2012 Sep; 14(5):591-602.
-
Wang X, Sutton VR, Eble TN, Lewis RA, Gunaratne P, Patel A, Van den Veyver IB. A genome-wide screen for copy number alterations in Aicardi syndrome. Am J Med Genet A. 2009 Oct; 149A(10):2113-21.
-
Rastogi R, Wu M, Dasgupta I, Fox GE. Visualization of ribosomal RNA operon copy number distribution. BMC Microbiol. 2009 Sep 25; 9:208.
-
Meisel RP. Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. J Mol Evol. 2009 Jul; 69(1):81-93.
-
Johnson JA, Vnencak-Jones CL, Cogan JD, Loyd JE, West J. Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension. BMC Med Genet. 2009 Jun 16; 10:58.
-
Meisel RP. Repeat mediated gene duplication in the Drosophila pseudoobscura genome. Gene. 2009 Jun 01; 438(1-2):1-7.
-
Mietkiewska E, Giblin EM, Wang S, Barton DL, Dirpaul J, Brost JM, Katavic V, Taylor DC. Seed-specific heterologous expression of a nasturtium FAE gene in Arabidopsis results in a dramatic increase in the proportion of erucic acid. Plant Physiol. 2004 Sep; 136(1):2665-75.
-
Stitzinger SM, Pellicena-Palle A, Albrecht EB, Gajewski KM, Beckingham KM, Salz HK. Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal. Mol Gen Genet. 1999 Feb; 261(1):142-51.
-
Ammons D, Rampersad J, Fox GE. 5S rRNA gene deletions cause an unexpectedly high fitness loss in Escherichia coli. Nucleic Acids Res. 1999 Jan 15; 27(2):637-42.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|