 Adenosine-5'-(N-ethylcarboxamide)
"Adenosine-5'-(N-ethylcarboxamide)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.
| Descriptor ID |
D019830
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| MeSH Number(s) |
D03.438.759.590.138.025 D13.570.583.138.025 D13.570.800.096.250
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| Concept/Terms |
Adenosine-5'-(N-ethylcarboxamide)- Adenosine-5'-(N-ethylcarboxamide)
- N6-Ethyl-carboxamido Adenosine
- Adenosine, N6-Ethyl-carboxamido
- N6 Ethyl carboxamido Adenosine
- NECA
- Adenosine-5'-N-ethyluronamide
- Adenosine 5' N ethyluronamide
- 5'-N-Ethylcarboxamidoadenosine
- 5' N Ethylcarboxamidoadenosine
- N-Ethylcarboxamidoadenosine
- N Ethylcarboxamidoadenosine
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Below are MeSH descriptors whose meaning is more general than "Adenosine-5'-(N-ethylcarboxamide)".
Below are MeSH descriptors whose meaning is more specific than "Adenosine-5'-(N-ethylcarboxamide)".
This graph shows the total number of publications written about "Adenosine-5'-(N-ethylcarboxamide)" by people in this website by year, and whether "Adenosine-5'-(N-ethylcarboxamide)" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1992 | 0 | 1 | 1 | | 1994 | 0 | 3 | 3 | | 1995 | 0 | 2 | 2 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Adenosine-5'-(N-ethylcarboxamide)" by people in Profiles.
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Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 2015 Nov; 98:68-77.
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Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. Br J Pharmacol. 2014 Aug; 171(16):3827-44.
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Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR. The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J. 2012 Jun; 26(6):2546-57.
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May LT, Bridge LJ, Stoddart LA, Briddon SJ, Hill SJ. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. FASEB J. 2011 Oct; 25(10):3465-76.
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Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. Br J Pharmacol. 2010 Feb; 159(4):772-86.
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May LT, Briddon SJ, Hill SJ. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Mol Pharmacol. 2010 Apr; 77(4):678-86.
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Cordeaux Y, Ijzerman AP, Hill SJ. Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. Br J Pharmacol. 2004 Nov; 143(6):705-14.
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Cooper J, Hill SJ, Alexander SP. An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. Br J Pharmacol. 1997 Oct; 122(3):546-50.
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Alexander SP, Cooper J, Shine J, Hill SJ. Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells. Br J Pharmacol. 1996 Nov; 119(6):1286-90.
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Peakman MC, Hill SJ. Adenosine A1 receptor-mediated inhibition of cyclic AMP accumulation in type-2 but not type-1 rat astrocytes. Eur J Pharmacol. 1996 Jun 13; 306(1-3):281-9.
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