 Receptor, Adenosine A1
"Receptor, Adenosine A1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.
| Descriptor ID |
D043682
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| MeSH Number(s) |
D12.776.543.750.100.700.700.100 D12.776.543.750.720.700.700.100
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| Concept/Terms |
Receptor, Adenosine A1- Receptor, Adenosine A1
- A1 Receptor, Adenosine
- Adenosine A1 Receptors
- A1 Receptors, Adenosine
- Receptors, Adenosine A1
- Adenosine A1 Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, Adenosine A1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Purinergic [D12.776.543.750.100.700]
- Receptors, Purinergic P1 [D12.776.543.750.100.700.700]
- Receptor, Adenosine A1 [D12.776.543.750.100.700.700.100]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Purinergic [D12.776.543.750.720.700]
- Receptors, Purinergic P1 [D12.776.543.750.720.700.700]
- Receptor, Adenosine A1 [D12.776.543.750.720.700.700.100]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Adenosine A1".
This graph shows the total number of publications written about "Receptor, Adenosine A1" by people in this website by year, and whether "Receptor, Adenosine A1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2004 | 2 | 1 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Adenosine A1" by people in Profiles.
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Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24; 58(24):9578-90.
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Hill SJ, May LT, Kellam B, Woolard J. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. Br J Pharmacol. 2014 Mar; 171(5):1102-13.
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Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. Br J Pharmacol. 2010 Feb; 159(4):772-86.
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May LT, Briddon SJ, Hill SJ. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Mol Pharmacol. 2010 Apr; 77(4):678-86.
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Briddon SJ, Gandía J, Amaral OB, Ferré S, Lluís C, Franco R, Hill SJ, Ciruela F. Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochim Biophys Acta. 2008 Dec; 1783(12):2262-8.
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Middleton RJ, Briddon SJ, Cordeaux Y, Yates AS, Dale CL, George MW, Baker JG, Hill SJ, Kellam B. New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells. J Med Chem. 2007 Feb 22; 50(4):782-93.
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Cordeaux Y, Ijzerman AP, Hill SJ. Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. Br J Pharmacol. 2004 Nov; 143(6):705-14.
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Briddon SJ, Middleton RJ, Cordeaux Y, Flavin FM, Weinstein JA, George MW, Kellam B, Hill SJ. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4673-8.
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Briddon SJ, Middleton RJ, Yates AS, George MW, Kellam B, Hill SJ. Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level. Faraday Discuss. 2004; 126:197-207; discussion 245-54.
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Hill KJ, Webber AC, Hill SJ. A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus. Br J Pharmacol. 2003 Jun; 139(4):721-32.
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