 Dithiothreitol
"Dithiothreitol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
| Descriptor ID |
D004229
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| MeSH Number(s) |
D02.033.800.196 D02.886.740.224 D09.853.196
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| Concept/Terms |
Dithiothreitol- Dithiothreitol
- Cleland's Reagent
- Clelands Reagent
- Reagent, Cleland's
- Cleland Reagent
- Reagent, Cleland
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Below are MeSH descriptors whose meaning is more general than "Dithiothreitol".
Below are MeSH descriptors whose meaning is more specific than "Dithiothreitol".
This graph shows the total number of publications written about "Dithiothreitol" by people in this website by year, and whether "Dithiothreitol" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 3 | 0 | 3 | | 1987 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dithiothreitol" by people in Profiles.
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Wang Y, Gibney PA, West JD, Morano KA. The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds. Mol Biol Cell. 2012 Sep; 23(17):3290-8.
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Weber TP, Widger WR, Kohn H. Metal-1,4-dithio-2,3-dihydroxybutane chelates: novel inhibitors of the Rho transcription termination factor. Biochemistry. 2003 Aug 05; 42(30):9121-6.
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Dickenson JM, Hill SJ. Selective potentiation of histamine H1-receptor stimulated calcium responses by 1,4-dithiothreitol in DDT1MF-2 cells. Biochem Pharmacol. 1994 Nov 01; 48(9):1721-8.
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Donaldson J, Hill SJ. 1,4-Dithiothreitol-induced changes in histamine H1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol. 1987 Jan; 90(1):263-71.
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Donaldson J, Hill SJ. Enhancement of histamine H1-receptor agonist activity by 1,4-dithiothreitol in guinea-pig cerebellum and cerebral cortex. J Neurochem. 1986 Nov; 47(5):1476-82.
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Donaldson J, Hill SJ. 1,4-Dithiothreitol-induced alteration in histamine H1-agonist binding in guinea-pig cerebellum and cerebral cortex. Eur J Pharmacol. 1986 Sep 23; 129(1-2):25-31.
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Donaldson J, Hill SJ. Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol. Br J Pharmacol. 1986 Jan; 87(1):191-9.
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