 Gene Amplification
"Gene Amplification" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
| Descriptor ID |
D005784
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| MeSH Number(s) |
G05.355.315.250 G05.355.600.315 G05.365.590.310
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Gene Amplification".
Below are MeSH descriptors whose meaning is more specific than "Gene Amplification".
This graph shows the total number of publications written about "Gene Amplification" by people in this website by year, and whether "Gene Amplification" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 1 | 0 | 1 | | 1985 | 0 | 1 | 1 | | 1987 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Amplification" by people in Profiles.
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Crafter C, Vincent JP, Tang E, Dudley P, James NH, Klinowska T, Davies BR. Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models. Int J Oncol. 2015 Aug; 47(2):446-54.
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Zufall RA, Robinson T, Katz LA. Evolution of developmentally regulated genome rearrangements in eukaryotes. J Exp Zool B Mol Dev Evol. 2005 Sep 15; 304(5):448-55.
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Ichimiya S, Nimura Y, Kageyama H, Takada N, Sunahara M, Shishikura T, Nakamura Y, Sakiyama S, Seki N, Ohira M, Kaneko Y, McKeon F, Caput D, Nakagawara A. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene. 1999 Jan 28; 18(4):1061-6.
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Cooper J, Hill SJ, Alexander SP. An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. Br J Pharmacol. 1997 Oct; 122(3):546-50.
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Knoll BJ, Rothblum KN, Longley M. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. Gene. 1987; 60(2-3):267-76.
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Yeung CY, Ingolia DE, Roth DB, Shoemaker C, Al-Ubaidi MR, Yen JY, Ching C, Bobonis C, Kaufman RJ, Kellems RE. Identification of functional murine adenosine deaminase cDNA clones by complementation in Escherichia coli. J Biol Chem. 1985 Aug 25; 260(18):10299-307.
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Yeung CY, Frayne EG, Al-Ubaidi MR, Hook AG, Ingolia DE, Wright DA, Kellems RE. Amplification and molecular cloning of murine adenosine deaminase gene sequences. J Biol Chem. 1983 Dec 25; 258(24):15179-85.
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