 Down-Regulation
"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
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| MeSH Number(s) |
G02.111.087.225 G02.149.115.225 G05.355.315.200 G07.690.773.937
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| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1999 | 2 | 2 | 4 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 1 | 2 | | 2002 | 0 | 4 | 4 | | 2003 | 1 | 1 | 2 | | 2004 | 2 | 3 | 5 | | 2005 | 0 | 4 | 4 | | 2006 | 1 | 2 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 2 | 2 | 4 | | 2010 | 1 | 2 | 3 | | 2011 | 0 | 4 | 4 | | 2012 | 0 | 4 | 4 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 2 | 2 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Kanlikilicer P, Zhang D, Dragomir A, Akay YM, Akay M. Gene expression profiling of midbrain dopamine neurons upon gestational nicotine exposure. Med Biol Eng Comput. 2017 Mar; 55(3):467-482.
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Alkadhi KA, Alhaider IA. Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1. Mol Cell Neurosci. 2016 Mar; 71:125-31.
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Thomas AL, Coarfa C, Qian J, Wilkerson JJ, Rajapakshe K, Krett NL, Gunaratne PH, Rosen ST. Identification of potential glucocorticoid receptor therapeutic targets in multiple myeloma. Nucl Recept Signal. 2015; 13:e006.
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Hampel U, Krüger M, Kunnen C, Garreis F, Willcox M, Paulsen F. In vitro effects of docosahexaenoic and eicosapentaenoic acid on human meibomian gland epithelial cells. Exp Eye Res. 2015 Nov; 140:139-148.
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van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11425-30.
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Chakravarti D, Su X, Cho MS, Bui NH, Coarfa C, Venkatanarayan A, Benham AL, Flores González RE, Alana J, Xiao W, Leung ML, Vin H, Chan IL, Aquino A, Müller N, Wang H, Cooney AJ, Parker-Thornburg J, Tsai KY, Gunaratne PH, Flores ER. Induced multipotency in adult keratinocytes through down-regulation of ?Np63 or DGCR8. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E572-81.
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Manhire-Heath R, Golenkina S, Saint R, Murray MJ. Netrin-dependent downregulation of Frazzled/DCC is required for the dissociation of the peripodial epithelium in Drosophila. Nat Commun. 2013; 4:2790.
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McFarlin BK, Johnston CJ, Carpenter KC, Davidson T, Moreno JL, Strohacker K, Breslin WL, Foreyt JP. A one-year school-based diet/exercise intervention improves non-traditional disease biomarkers in Mexican-American children. Matern Child Nutr. 2013 Oct; 9(4):524-32.
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Liu C, Goswami M, Talley J, Chesser-Martinez PL, Lou CH, Sater AK. TAK1 promotes BMP4/Smad1 signaling via inhibition of erk MAPK: a new link in the FGF/BMP regulatory network. Differentiation. 2012 Apr; 83(4):210-9.
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Carter J, Vaitaitis GM, Waid DM, Wagner DH. CD40 engagement of CD4+ CD40+ T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance. Eur J Immunol. 2012 Feb; 42(2):424-35.
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