 Histamine H1 Antagonists
"Histamine H1 Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
| Descriptor ID |
D006634
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| MeSH Number(s) |
D27.505.519.625.375.425.400 D27.505.696.577.375.425.400
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| Concept/Terms |
Histamine H1 Antagonists- Histamine H1 Antagonists
- H1 Antagonists, Histamine
- Antagonists, Histamine H1 Receptor
- Antihistaminics, H1
- H1 Antihistaminics
- Receptor Blockaders, H1
- H1 Receptor Blockaders
- Histamine H1 Blockers
- Histamine H1 Receptor Antagonists
- Histamine H1 Receptor Blockaders
- Antagonists, Histamine H1
- Blockaders, Histamine H1 Receptor
Antihistamines, Classical- Antihistamines, Classical
- Classical Antihistamines
- Antihistaminics, Classical
- Classical Antihistaminics
- First Generation H1 Antagonists
- Antihistamines, Sedating
- Sedating Antihistamines
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Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Histamine H1 Antagonists".
This graph shows the total number of publications written about "Histamine H1 Antagonists" by people in this website by year, and whether "Histamine H1 Antagonists" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 1 | 1 | 2 | | 1982 | 1 | 0 | 1 | | 1987 | 0 | 1 | 1 | | 1988 | 1 | 0 | 1 | | 1994 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histamine H1 Antagonists" by people in Profiles.
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Mach CM, Lapp EA, Weddle KJ, Hunter RJ, Burns KA, Parker C, Brown J, Smith JA. Adjunct Histamine Blockers as Premedications to Prevent Carboplatin Hypersensitivity Reactions. Pharmacotherapy. 2016 May; 36(5):482-7.
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Rose RH, Briddon SJ, Hill SJ. A novel fluorescent histamine H(1) receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands. Br J Pharmacol. 2012 Mar; 165(6):1789-1800.
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Self TJ, Oakley SM, Hill SJ. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells. Br J Pharmacol. 2005 Oct; 146(4):612-24.
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Sansgiry SS, Shringarpure GS. Springtime confusion: are consumers getting the right information on how to treat seasonal allergies? J Allergy Clin Immunol. 2003 Sep; 112(3):627-8.
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Peakman MC, Hill SJ. Endogenous expression of histamine H1 receptors functionally coupled to phosphoinositide hydrolysis in C6 glioma cells: regulation by cyclic AMP. Br J Pharmacol. 1994 Dec; 113(4):1554-60.
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Young CS, Mason R, Hill SJ. Inhibition by H1-antihistamines of the uptake of noradrenaline and 5-HT into rat brain synaptosomes. Biochem Pharmacol. 1988 Mar 01; 37(5):976-8.
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Donaldson J, Hill SJ. 1,4-Dithiothreitol-induced changes in histamine H1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol. 1987 Jan; 90(1):263-71.
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Kador PF, Sharpless NE, Goosey JD. Aldose reductase inhibition by anti-allergy drugs. Prog Clin Biol Res. 1982; 114:243-59.
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Hill SJ, Daum P, Young JM. Affinities of histamine H1-antagonists in guinea pig brain: similarity of values determined from [3H]mepyramine binding and from inhibition of a functional response. J Neurochem. 1981 Nov; 37(5):1357-60.
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Hill SJ, Young JM. Characterization of [3H]mepyramine binding to the longitudinal muscle of guinea pig small intestine. Mol Pharmacol. 1981 May; 19(3):379-87.
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