 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 0 | 1 | | 2005 | 3 | 0 | 3 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 3 | 2 | 5 | | 2009 | 2 | 1 | 3 | | 2010 | 1 | 5 | 6 | | 2011 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Li Y, Cirino PC. Recent advances in engineering proteins for biocatalysis. Biotechnol Bioeng. 2014 Jul; 111(7):1273-87.
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Hussain F, Gupta C, Hirning AJ, Ott W, Matthews KS, Josic K, Bennett MR. Engineered temperature compensation in a synthetic genetic clock. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):972-7.
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Tang SY, Qian S, Akinterinwa O, Frei CS, Gredell JA, Cirino PC. Screening for enhanced triacetic acid lactone production by recombinant Escherichia coli expressing a designed triacetic acid lactone reporter. J Am Chem Soc. 2013 Jul 10; 135(27):10099-103.
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Ramesh B, Sendra VG, Cirino PC, Varadarajan N. Single-cell characterization of autotransporter-mediated Escherichia coli surface display of disulfide bond-containing proteins. J Biol Chem. 2012 Nov 09; 287(46):38580-9.
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Gredell JA, Frei CS, Cirino PC. Protein and RNA engineering to customize microbial molecular reporting. Biotechnol J. 2012 Apr; 7(4):477-99.
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Lizak C, Fan YY, Weber TC, Aebi M. N-Linked glycosylation of antibody fragments in Escherichia coli. Bioconjug Chem. 2011 Mar 16; 22(3):488-96.
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Tang SY, Cirino PC. Design and application of a mevalonate-responsive regulatory protein. Angew Chem Int Ed Engl. 2011 Feb 01; 50(5):1084-6.
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Simpson RJ. Small-scale extraction of recombinant proteins from bacteria. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5483.
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Simpson RJ. Large-scale extraction of recombinant proteins from bacteria. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5484.
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Simpson RJ. Solubilization of Escherichia coli recombinant proteins from inclusion bodies. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5485.
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