 Proto-Oncogene Proteins c-akt
"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
| Descriptor ID |
D051057
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| MeSH Number(s) |
D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
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| Concept/Terms |
Proto-Oncogene Proteins c-akt- Proto-Oncogene Proteins c-akt
- Proto Oncogene Proteins c akt
- c-akt, Proto-Oncogene Proteins
- c-akt Protein
- c-akt Proto-Oncogene Protein
- Protein, c-akt Proto-Oncogene
- Proto-Oncogene Protein, c-akt
- c akt Proto Oncogene Protein
- Protein Kinase B
- Protein-Serine-Threonine Kinase (Rac)
- Proto-Oncogene Protein RAC
- Proto Oncogene Protein RAC
- RAC, Proto-Oncogene Protein
- Rac Protein Kinase
- RAC-PK Protein
- RAC PK Protein
- Related to A and C-Protein
- Related to A and C Protein
- akt Proto-Oncogene Protein
- Protein, akt Proto-Oncogene
- Proto-Oncogene Protein, akt
- akt Proto Oncogene Protein
- Proto-Oncogene Protein Akt
- Akt, Proto-Oncogene Protein
- Proto Oncogene Protein Akt
Proto-Oncogene Proteins c-akt3- Proto-Oncogene Proteins c-akt3
- Proteins c-akt3, Proto-Oncogene
- Proto Oncogene Proteins c akt3
- c-akt3, Proto-Oncogene Proteins
- AKT3 Protein Kinase
- Protein Kinase B gamma
- Akt-gamma Protein
- Akt gamma Protein
Proto-Oncogene Proteins c-akt1- Proto-Oncogene Proteins c-akt1
- Proteins c-akt1, Proto-Oncogene
- Proto Oncogene Proteins c akt1
- c-akt1, Proto-Oncogene Proteins
- Rac-PK alpha Protein
- Rac PK alpha Protein
- alpha Protein, Rac-PK
- Protein Kinase B alpha
- Akt-alpha Protein
- Akt alpha Protein
- AKT1 Protein Kinase
Proto-Oncogene Proteins c-akt2- Proto-Oncogene Proteins c-akt2
- Proteins c-akt2, Proto-Oncogene
- Proto Oncogene Proteins c akt2
- c-akt2, Proto-Oncogene Proteins
- Rac-PK beta Protein
- Rac PK beta Protein
- Protein Kinase B beta
- Akt-beta Protein
- Akt beta Protein
- AKT2 Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 3 | 1 | 4 | | 2009 | 1 | 2 | 3 | | 2010 | 1 | 2 | 3 | | 2011 | 2 | 1 | 3 | | 2013 | 1 | 3 | 4 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.
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Crafter C, Vincent JP, Tang E, Dudley P, James NH, Klinowska T, Davies BR. Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models. Int J Oncol. 2015 Aug; 47(2):446-54.
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Rapp M, Woo G, Al-Ubaidi MR, Becerra SP, Subramanian P. Pigment epithelium-derived factor protects cone photoreceptor-derived 661W cells from light damage through Akt activation. Adv Exp Med Biol. 2014; 801:813-20.
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Zhou Y, Bollu LR, Tozzi F, Ye X, Bhattacharya R, Gao G, Dupre E, Xia L, Lu J, Fan F, Bellister S, Ellis LM, Weihua Z. ATP citrate lyase mediates resistance of colorectal cancer cells to SN38. Mol Cancer Ther. 2013 Dec; 12(12):2782-91.
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Ishikawa T, Yuhanna IS, Umetani J, Lee WR, Korach KS, Shaul PW, Umetani M. LXRß/estrogen receptor-a signaling in lipid rafts preserves endothelial integrity. J Clin Invest. 2013 Aug; 123(8):3488-97.
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Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. Prostate. 2013 Sep; 73(13):1453-61.
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McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One. 2013; 8(3):e56576.
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Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 2011 Dec; 25(12):2106-18.
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Kim EY, Dryer SE. Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes. J Cell Physiol. 2011 Sep; 226(9):2307-15.
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Föller M, Kempe DS, Boini KM, Pathare G, Siraskar B, Capuano P, Alesutan I, Sopjani M, Stange G, Mohebbi N, Bhandaru M, Ackermann TF, Judenhofer MS, Pichler BJ, Biber J, Wagner CA, Lang F. PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria. J Am Soc Nephrol. 2011 May; 22(5):873-80.
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Anderson M, Suh JM, Kim EY, Dryer SE. Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C22-32.
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