 Alkylation
"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
| Descriptor ID |
D000478
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| MeSH Number(s) |
G02.111.087.029 G02.149.115.029 G02.149.465.040 G02.607.750.040 G03.495.130
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Alkylation".
Below are MeSH descriptors whose meaning is more specific than "Alkylation".
This graph shows the total number of publications written about "Alkylation" by people in this website by year, and whether "Alkylation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 5 | 5 | | 2011 | 0 | 4 | 4 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 |
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Below are the most recent publications written about "Alkylation" by people in Profiles.
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Grigorjeva L, Daugulis O. Cobalt-catalyzed, aminoquinoline-directed C(sp²)-H bond alkenylation by alkynes. Angew Chem Int Ed Engl. 2014 Sep 15; 53(38):10209-12.
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Han SJ, Vogt F, Krishnan S, May JA, Gatti M, Virgil SC, Stoltz BM. A diastereodivergent synthetic strategy for the syntheses of communesin F and perophoramidine. Org Lett. 2014 Jun 20; 16(12):3316-9.
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Nadres ET, Santos GI, Shabashov D, Daugulis O. Scope and limitations of auxiliary-assisted, palladium-catalyzed arylation and alkylation of sp2 and sp3 C-H bonds. J Org Chem. 2013 Oct 04; 78(19):9689-714.
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Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-p interactions. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18755-60.
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Laha JK, Cuny GD. Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter a to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J Org Chem. 2011 Oct 21; 76(20):8477-82.
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West JD, Stamm CE, Brown HA, Justice SL, Morano KA. Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chem Res Toxicol. 2011 Sep 19; 24(9):1457-9.
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Truong T, Daugulis O. Transition-metal-free alkynylation of aryl chlorides. Org Lett. 2011 Aug 19; 13(16):4172-5.
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Garnsey MR, Matous JA, Kwiek JJ, Coltart DM. Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2406-9.
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Krenske EH, Houk KN, Lim D, Wengryniuk SE, Coltart DM. Origins of stereoselectivity in the a-alkylation of chiral hydrazones. J Org Chem. 2010 Dec 17; 75(24):8578-84.
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Garnsey MR, Lim D, Yost JM, Coltart DM. Development of a strategy for the asymmetric synthesis of polycyclic polyprenylated acylphloroglucinols via N-amino cyclic carbamate hydrazones: application to the total synthesis of (+)-clusianone. Org Lett. 2010 Nov 19; 12(22):5234-7.
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