 Binding, Competitive
"Binding, Competitive" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
| Descriptor ID |
D001667
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| MeSH Number(s) |
E05.196.080 G02.111.087.090 G02.111.570.120.309 G02.149.115.090
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Binding, Competitive".
Below are MeSH descriptors whose meaning is more specific than "Binding, Competitive".
This graph shows the total number of publications written about "Binding, Competitive" by people in this website by year, and whether "Binding, Competitive" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 1 | 1 | | 1986 | 0 | 1 | 1 | | 1987 | 0 | 1 | 1 | | 1993 | 0 | 2 | 2 | | 1994 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 3 | 3 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Binding, Competitive" by people in Profiles.
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Porter AH, Johnson NA, Tulchinsky AY. A New Mechanism for Mendelian Dominance in Regulatory Genetic Pathways: Competitive Binding by Transcription Factors. Genetics. 2017 Jan; 205(1):101-112.
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Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24; 58(24):9578-90.
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Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B. Synthesis and in vitro and in vivo characterization of highly ß1-selective ß-adrenoceptor partial agonists. J Med Chem. 2013 May 23; 56(10):3852-65.
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Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15; 427(2):164-74.
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Bridge LJ, King JR, Hill SJ, Owen MR. Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition. Math Biosci. 2010 Feb; 223(2):115-32.
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Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 01; 69(15):6232-40.
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Udugamasooriya DG, Ritchie C, Brekken RA, Kodadek T. A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site. Bioorg Med Chem. 2008 Jun 15; 16(12):6338-43.
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Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. FASEB J. 2008 Mar; 22(3):850-60.
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Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med. 2007 Oct; 13(10):1185-92.
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Baker JG, Hill SJ. Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates. Trends Pharmacol Sci. 2007 Aug; 28(8):374-81.
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