 G-Protein-Coupled Receptor Kinase 3
"G-Protein-Coupled Receptor Kinase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response.
| Descriptor ID |
D054770
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| MeSH Number(s) |
D08.811.913.696.620.682.700.364.049.300 D12.644.360.293.249.300 D12.776.476.293.249.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinase 3".
Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinase 3".
This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinase 3" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinase 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2007 | 0 | 3 | 3 | | 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "G-Protein-Coupled Receptor Kinase 3" by people in Profiles.
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Taneja M, Salim S, Saha K, Happe HK, Qutna N, Petty F, Bylund DB, Eikenburg DC. Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience. Behav Brain Res. 2011 Aug 01; 221(1):25-33.
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Bawa-Khalfe T, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007 Dec 20; 7:16.
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Salim S, Hite B, Eikenburg DC. Activation of the CRF(1) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells. FEBS Lett. 2007 Jul 10; 581(17):3204-10.
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Salim S, Standifer KM, Eikenburg DC. Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells. J Pharmacol Exp Ther. 2007 Apr; 321(1):51-9.
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Salim S, Eikenburg DC. Role of 90-kDa heat shock protein (Hsp 90) and protein degradation in regulating neuronal levels of G protein-coupled receptor kinase 3. J Pharmacol Exp Ther. 2007 Mar; 320(3):1106-12.
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Desai AN, Salim S, Standifer KM, Eikenburg DC. Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor. J Pharmacol Exp Ther. 2006 Jun; 317(3):1027-35.
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Iyer V, Tran TM, Foster E, Dai W, Clark RB, Knoll BJ. Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol. 2006 Feb; 147(3):249-59.
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Desai AN, Standifer KM, Eikenburg DC. Simultaneous alpha2B- and beta2-adrenoceptor activation sensitizes the alpha2B-adrenoceptor for agonist-induced down-regulation. J Pharmacol Exp Ther. 2004 Nov; 311(2):794-802.
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Bawa T, Altememi GF, Eikenburg DC, Standifer KM. Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation. Br J Pharmacol. 2003 Mar; 138(5):921-31.
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Nagaraja S, Iyer S, Liu X, Eichberg J, Bond RA. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation. Br J Pharmacol. 1999 Jul; 127(5):1099-104.
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