 Receptors, Adrenergic, alpha-2
"Receptors, Adrenergic, alpha-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
| Descriptor ID |
D018341
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| MeSH Number(s) |
D12.776.543.750.069.300.300.300.200 D12.776.543.750.100.150.300.300.725 D12.776.543.750.720.330.300.300.200
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| Concept/Terms |
Receptors, Adrenergic, alpha-2- Receptors, Adrenergic, alpha-2
- Adrenergic alpha-2 Receptors
- Adrenergic alpha 2 Receptors
- Receptors, Adrenergic alpha-2
- alpha-2 Receptors, Adrenergic
- Receptor, Adrenergic, alpha-2
- alpha 2 Adrenergic Receptors
- alpha-2 Adrenergic Receptors
- Adrenergic Receptors, alpha-2
- Receptors, alpha-2 Adrenergic
- Receptors, alpha 2 Adrenergic
- Adrenergic Receptor, alpha-2
- Adrenergic Receptor, alpha 2
- Receptor, alpha-2 Adrenergic
- alpha-2 Adrenergic Receptor
Receptor, Adrenergic, alpha-2D- Receptor, Adrenergic, alpha-2D
- Receptors, Adrenergic, alpha-2D
- alpha-2D Adrenergic Receptor
- Adrenergic Receptor, alpha-2D
- Receptor, alpha-2D Adrenergic
- alpha 2D Adrenergic Receptor
- Adrenergic alpha-2D Receptors
- Adrenergic alpha 2D Receptors
- Receptors, Adrenergic alpha-2D
- alpha-2D Receptors, Adrenergic
- Adrenergic Receptor alpha(2d)
Receptor, Adrenergic, alpha-2C- Receptor, Adrenergic, alpha-2C
- alpha-2C Adrenergic Receptor
- Adrenergic Receptor, alpha-2C
- Receptor, alpha-2C Adrenergic
- alpha 2C Adrenergic Receptor
- Adrenergic Receptor alpha-2C
- Adrenergic Receptor alpha 2C
- Receptor alpha-2C, Adrenergic
- alpha-2C, Adrenergic Receptor
- Adrenergic alpha-2C Receptors
- Adrenergic alpha 2C Receptors
- Receptors, Adrenergic alpha-2C
- alpha-2C Receptors, Adrenergic
- Adrenergic Receptor alpha(2C)
Receptor, Adrenergic, alpha-2A- Receptor, Adrenergic, alpha-2A
- alpha-2A Adrenergic Receptor
- Adrenergic Receptor, alpha-2A
- Receptor, alpha-2A Adrenergic
- alpha 2A Adrenergic Receptor
- Receptors, Adrenergic, alpha-2A
- Adrenergic alpha-2A Receptors
- Adrenergic alpha 2A Receptors
- Receptors, Adrenergic alpha-2A
- alpha-2A Receptors, Adrenergic
Receptor, Adrenergic, alpha-2B- Receptor, Adrenergic, alpha-2B
- Receptors, Adrenergic, alpha-2B
- alpha-2B Adrenergic Receptor
- Adrenergic Receptor, alpha-2B
- Receptor, alpha-2B Adrenergic
- alpha 2B Adrenergic Receptor
- Adrenergic alpha-2B Receptors
- Adrenergic alpha 2B Receptors
- Receptors, Adrenergic alpha-2B
- alpha-2B Receptors, Adrenergic
- Adrenergic Receptor alpha-2b
- Adrenergic Receptor alpha 2b
- Receptor alpha-2b, Adrenergic
- alpha-2b, Adrenergic Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptors, Adrenergic, alpha-2".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.069]
- Receptors, Catecholamine [D12.776.543.750.069.300]
- Receptors, Adrenergic [D12.776.543.750.069.300.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.069.300.300.300]
- Receptors, Adrenergic, alpha-2 [D12.776.543.750.069.300.300.300.200]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Catecholamine [D12.776.543.750.100.150]
- Receptors, Adrenergic [D12.776.543.750.100.150.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.100.150.300.300]
- Receptors, Adrenergic, alpha-2 [D12.776.543.750.100.150.300.300.725]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Catecholamine [D12.776.543.750.720.330]
- Receptors, Adrenergic [D12.776.543.750.720.330.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.720.330.300.300]
- Receptors, Adrenergic, alpha-2 [D12.776.543.750.720.330.300.300.200]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Adrenergic, alpha-2".
This graph shows the total number of publications written about "Receptors, Adrenergic, alpha-2" by people in this website by year, and whether "Receptors, Adrenergic, alpha-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Adrenergic, alpha-2" by people in Profiles.
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Taneja M, Salim S, Saha K, Happe HK, Qutna N, Petty F, Bylund DB, Eikenburg DC. Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience. Behav Brain Res. 2011 Aug 01; 221(1):25-33.
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Salim S, Desai AN, Taneja M, Eikenburg DC. Chronic adrenaline treatment fails to down-regulate the Del301-303-alpha2B-adrenoceptor in neuronal cells. Br J Pharmacol. 2009 Sep; 158(1):314-27.
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Bawa-Khalfe T, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007 Dec 20; 7:16.
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Desai AN, Salim S, Standifer KM, Eikenburg DC. Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor. J Pharmacol Exp Ther. 2006 Jun; 317(3):1027-35.
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Desai AN, Standifer KM, Eikenburg DC. Cellular G protein-coupled receptor kinase levels regulate sensitivity of the {alpha}2b-adrenergic receptor to undergo agonist-induced down-regulation. J Pharmacol Exp Ther. 2005 Feb; 312(2):767-73.
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Desai AN, Standifer KM, Eikenburg DC. Simultaneous alpha2B- and beta2-adrenoceptor activation sensitizes the alpha2B-adrenoceptor for agonist-induced down-regulation. J Pharmacol Exp Ther. 2004 Nov; 311(2):794-802.
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Bawa T, Altememi GF, Eikenburg DC, Standifer KM. Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation. Br J Pharmacol. 2003 Mar; 138(5):921-31.
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Wilborn TW, Sun D, Schafer JA. Expression of multiple alpha-adrenoceptor isoforms in rat CCD. Am J Physiol. 1998 Jul; 275(1 Pt 2):F111-8.
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